ArticleDevelopmental cell2006
Quantifying the Gurken morphogen gradient in Drosophila oogenesis.
Article in Developmental cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 86 citations in OpenAlex.
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- The pattern of the follicle cell diversification in ovarian follicles of the true fruit flies, Tephritidae.Journal of anatomy · 2024Article
- Finishing the egg.Genetics · 2024Article
- Stochastic phenotypes in RAS-dependent developmental diseases.Current biology : CB · 2023Article
- Patterning principles of morphogen gradients.Open biology · 2022Review
- Quantitative analyses of EGFR localization and trafficking dynamics in the follicular epithelium.Development (Cambridge, England) · 2020Article
- Functional divergence caused by mutations in an energetic hotspot in ERK2.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila.PLoS genetics · 2019Article
- Imaging Cytonemes in Drosophila Embryos.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Two Drosophilids exhibit distinct EGF pathway patterns in oogenesis.Development genes and evolution · 2018Article
- Gene regulation duringProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Epithelial Patterning, Morphogenesis, and Evolution: Drosophila Eggshell as a Model.Developmental cell · 2017Review
- Complex structures from patterned cell sheets.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Improving Parameter Inference from FRAP Data: an Analysis Motivated by Pattern Formation in the Drosophila Wing Disc.Bulletin of mathematical biology · 2017Article
- Stratum, a Homolog of the Human GEF Mss4, Partnered with Rab8, Controls the Basal Restriction of Basement Membrane Proteins in Epithelial Cells.Cell reports · 2017Article
- Control of reaction-diffusion equations on time-evolving manifolds.Proceedings of the ... IEEE Conference on Decision & Control. IEEE Conference on Decision & Control · 2016Article
- Automatic stage identification of Drosophila egg chamber based on DAPI images.Scientific reports · 2016Article
- Evolutionary changes in TGFα distribution underlie morphological diversity in eggshells from Drosophila species.Development (Cambridge, England) · 2014Article
- Inferring alterations in cell-to-cell communication in HER2+ breast cancer using secretome profiling of three cell models.Biotechnology and bioengineering · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Quantitative information about the distribution of morphogens is crucial for understanding their effects on cell-fate determination, yet it is difficult to obtain through direct measurements. We have developed a parameter estimation approach for quantifying the spatial distribution of Gurken, a TGFalpha-like EGFR ligand that acts as a morphogen in Drosophila oogenesis. Modeling of Gurken/EGFR system shows that the shape of the Gurken gradient is controlled by a single dimensionless parameter, the Thiele modulus, which reflects the relative importance of ligand diffusion and degradation. By combining the model with genetic alterations of EGFR levels, we have estimated the value of the Thiele modulus in the wild-type egg chamber. This provides a direct characterization of the shape of the Gurken gradient and demonstrates how parameter estimation techniques can be used to quantify morphogen gradients in development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.