Evidence map›Paper›PMID 16889661›Full record

ArticleGenome biology2006

Zebrafish promoter microarrays identify actively transcribed embryonic genes.

Fiona C Wardle, Duncan T Odom, George W Bell, Bingbing Yuan, Timothy W Danford, Elizabeth L Wiellette, Elizabeth Herbolsheimer, Hazel L Sive, Richard A Young, James C Smith

Abstract readComparative Study
In one paragraph

Article in Genome biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Review
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  11. UXT potentiates angiogenesis by attenuating Notch signaling.Development (Cambridge, England) · 2015
    Article
  12. Cross-species oncogenomics using zebrafish models of cancer.Current opinion in genetics & development · 2015
    Review
  13. Fgf-signaling-dependent Sox9a and Atoh1a regulate otic neural development in zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
    Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fiona C WardleWellcome Trust/Cancer Research UK Gurdon Institute and Department of Zoology, Cambridge University, Cambridge, UK. fcw27@cam.ac.uk
Duncan T Odom
George W Bell
Bingbing Yuan
Timothy W Danford
Elizabeth L Wiellette
Elizabeth Herbolsheimer
Hazel L Sive
Richard A Young
James C Smith

Funding

Transcriptional Regulatory Networks in Living CellsR01HG002668 · NHGRI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI YOUNG, RICHARD · 2003 to 2016
$17.9M
ANTEROPOSTERIOR ECTODERMAL PATTERNING IN XENOPUSR01HD033472 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI SIVE, HAZEL L · 1997 to 2006
$2.1M
ZEBRAFISH NEUROGENESIS-- EMBRYOLOGY AND GENETICSR01MH059942 · NIMH · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI SIVE, HAZEL L · 2000 to 2004
$1.5M
Insulin Regulators and Control of Islet TranscriptionK25DK070813 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI ODOM, DUNCAN T · 2005 to 2006
$183k
NHGRI NIH HHS HG002668NHGRI NIH HHS R01 HG002668NICHD NIH HHS 2R01 HD33472NICHD NIH HHS R01 HD033472NIDDK NIH HHS DK070813NIDDK NIH HHS K25 DK070813NIMH NIH HHS 5R01 MH59942NIMH NIH HHS R01 MH059942Wellcome Trust
6 · The paper itself

Abstract

We have designed a zebrafish genomic microarray to identify DNA-protein interactions in the proximal promoter regions of over 11,000 zebrafish genes. Using these microarrays, together with chromatin immunoprecipitation with an antibody directed against tri-methylated lysine 4 of Histone H3, we demonstrate the feasibility of this method in zebrafish. This approach will allow investigators to determine the genomic binding locations of DNA interacting proteins during development and expedite the assembly of the genetic networks that regulate embryogenesis.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsChromatin ImmunoprecipitationEmbryo, NonmammalianGenesGenomicsHistonesOligonucleotide Array Sequence AnalysisPromoter Regions, GeneticReverse Transcriptase Polymerase Chain ReactionZebrafishHistones

Identifiers

PMID16889661
PMCPMC1779600

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.