ReviewDialogues in clinical neuroscience2006
Somatic symptoms in depression.
Review in Dialogues in clinical neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
124 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of vortioxetine on the physical symptoms of major depressive disorder.Journal of psychopharmacology (Oxford, England) · 2018Pooled it
- Patient perspectives on group problem management plus for adults with major depressive disorder in rural Malawi.Global health action · 2025Trial
- Protocol for mixed methods study exploring the gut-brain health among South Indian population.BMJ open · 2026Article
- Prevalence and Associated Risk Factors of Psychiatric Comorbidities Among the Hospitalized Patients in Bangladesh: A Cross-Sectional Study.Health science reports · 2026Article
- Predictors of Somatic Symptom Severity in Adult Psychiatric Outpatients: A Cross-sectional Heart Rate Variability and Quantitative Electroencephalography Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Associations between other-directed ageism, subjective views on aging, and mental health among middle-aged Japanese adults: a cross-sectional path analysis.Archives of public health = Archives belges de sante publique · 2026Article
- "I wanna just not go, because maybe I'm sad" - views on depression from the perspective of people with aphasia, their care partners, and speech-language pathologists.Disability and rehabilitation · 2026Article
- Brain-heart interactions in late-onset major depressive disorder revealed by multimodal HRV-driven fMRI.Communications biology · 2026Article
- Raphe subregion seeds reveal whole-brain functional connectivity differences underlying adolescent depression.BMC psychiatry · 2026Article
- Understanding depression symptom heterogeneity in South Asian minority groups: systematic scoping review.The British journal of psychiatry : the journal of mental science · 2026Article
- Low Back Pain in Korea: Survey Weighted Analysis with Age Sex and Lumbar Radiographic Grade Matching.Healthcare (Basel, Switzerland) · 2026Article
- Depressive symptoms and cardiometabolic diseases in Chinese middle-aged and older adults: a longitudinal cross-lagged analysis.BMC public health · 2026Article
- Understanding the interplay between somatic symptoms, depression, self-efficacy, and suicide risk among Latinx college students.Journal of affective disorders · 2026Article
- Recognition of depression by nurses in primary healthcare in Zimbabwe: Cross-sectional study.Global mental health (Cambridge, England) · 2026Article
- Bipolar disorder and somatic diseases: Focus on oxidative stress markers.Neuroscience applied · 2026Review
- Cross-sectional and longitudinal functional network alterations associated with subthreshold depressive symptoms in healthy older adults.Frontiers in aging neuroscience · 2026Article
- Subjective Health Perception Moderates the Antidepressant Effects of Home-Based Transcranial Direct Current Stimulation in Perinatal Women: A Real-World Observational Study.Psychiatry investigation · 2026Article
- Association Between Circulating Cytokines and Psychosomatic Syndromes in Patients with Mood Disorders.Clinical neuropsychiatry · 2025Article
- Gender differences in symptom profiles of individuals being treated for mood disorders.Journal of mood and anxiety disorders · 2025Article
- The effects of polygenic risks for alcohol misuse on negative emotion processing in young adult binge drinkers.Translational psychiatry · 2025Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both painful and nonpainful somatic symptoms essentially characterize clinical states of depressive mood. So far, this well-established psychopathological knowledge has been appreciated only insufficiently by the official diagnostic systerms of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Text Revision (DSM-IV TR) and the ICD-10 Classification of Mental and Behavioral Disorders. Clinical Descriptions and Diagnostic Guidelines (ICD-10). From a perspective of primary care services, this unmet diagnostic need is deplorable, as the main mode of presenting a depression is by reporting somatic symptoms. This somatic form of presentation, however, significantly contributes to low rates of recognition in primary care. A diagnostic challenge may be seen in the differentiation of a depression with prevailing somatic symptoms from anxiety, somatoform disorders, and medical conditions. When somatic symptoms, particularly painful physical conditions, accompany the already debilitating psychiatric and behavioral symptoms of depression, the course of the illness may be more severe, implying a higher risk of early relapse, chronicity, suicide, or mortality due to other natural causes, the economic burden increases considerably the functional status may be hampered heavily, and health-related quality of life may be lowered dramatically. The neurobiological underpinnings of somatic symptoms in depression may guide more promising treatment approaches.
Indexed as
Identifiers
16889108PMC3181769What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.