ArticleThe EMBO journal2006
Nud1p, the yeast homolog of Centriolin, regulates spindle pole body inheritance in meiosis.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Membrane and organelle rearrangement during ascospore formation in budding yeast.Microbiology and molecular biology reviews : MMBR · 2024Review
- Meiotic Cytokinesis inJournal of fungi (Basel, Switzerland) · 2024Review
- The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast.The EMBO journal · 2022Article
- A Noncanonical Hippo Pathway Regulates Spindle Disassembly and Cytokinesis During Meiosis inGenetics · 2020Article
- Article
- Yeast pericentrin/Spc110 contains multiple domains required for tethering the γ-tubulin complex to the centrosome.Molecular biology of the cell · 2020Article
- Scalable phylogenetic profiling using MinHash uncovers likely eukaryotic sexual reproduction genes.PLoS computational biology · 2020Article
- The half-bridge component Kar1 promotes centrosome separation and duplication during budding yeast meiosis.Molecular biology of the cell · 2018Article
- Budding yeast Wee1 distinguishes spindle pole bodies to guide their pattern of age-dependent segregation.Nature cell biology · 2017Article
- Article
- Attaching to spindles before they form: do early incorrect chromosome-microtubule attachments promote meiotic segregation fidelity?Cell cycle (Georgetown, Tex.) · 2013Review
- Control of the mitotic exit network during meiosis.Molecular biology of the cell · 2012Article
- Acetate regulation of spore formation is under the control of the Ras/cyclic AMP/protein kinase A pathway and carbon dioxide in Saccharomyces cerevisiae.Eukaryotic cell · 2012Article
- Article
- Sporulation in the budding yeast Saccharomyces cerevisiae.Genetics · 2011Review
- Exploiting spore-autonomous fluorescent protein expression to quantify meiotic chromosome behaviors in Saccharomyces cerevisiae.Genetics · 2011Article
- Combination of genomic approaches with functional genetic experiments reveals two modes of repression of yeast middle-phase meiosis genes.BMC genomics · 2010Article
- Septins: molecular partitioning and the generation of cellular asymmetry.Cell division · 2009Article
- Cdc15 is required for spore morphogenesis independently of Cdc14 in Saccharomyces cerevisiae.Genetics · 2007Article
- Cytokinesis in yeast meiosis depends on the regulated removal of Ssp1p from the prospore membrane.The EMBO journal · 2007Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nud1p, a protein homologous to the mammalian centrosome and midbody component Centriolin, is a component of the budding yeast spindle pole body (SPB), with roles in anchorage of microtubules and regulation of the mitotic exit network during vegetative growth. Here we analyze the function of Nud1p during yeast meiosis. We find that a nud1-2 temperature-sensitive mutant has two meiosis-related defects that reflect genetically distinct functions of Nud1p. First, the mutation affects spore formation due to its late function during spore maturation. Second, and most important, the mutant loses its ability to distinguish between the ages of the four spindle pole bodies, which normally determine which SPB would be preferentially included in the mature spores. This affects the regulation of genome inheritance in starved meiotic cells and leads to the formation of random dyads instead of non-sister dyads under these conditions. Both functions of Nud1p are connected to the ability of Spc72p to bind to the outer plaque and half-bridge (via Kar1p) of the SPB.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.