ArticleThe EMBO journal2006
Spo0A, the key transcriptional regulator for entrance into sporulation, is an inhibitor of DNA replication.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Robust helicase loading mechanism underlies diverse architectures of bacterial replication origins.Nucleic acids research · 2026Article
- Evolving a plant-beneficial bacterium in soil vs. nutrient-rich liquid culture has contrasting effects on in-soil fitness.Applied and environmental microbiology · 2025Article
- Review
- Bacterium secretes chemical inhibitor that sensitizes competitor to bacteriophage infection.bioRxiv : the preprint server for biology · 2024Article
- AdpA Positively Regulates Morphological Differentiation and Chloramphenicol Biosynthesis in Streptomyces venezuelae.Microbiology spectrum · 2021Article
- Pervasive prophage recombination occurs during evolution of spore-forming Bacilli.The ISME journal · 2021Article
- TheGenes · 2020Article
- Structure and Function of theFrontiers in microbiology · 2018Article
- Review
- Random versus Cell Cycle-Regulated Replication Initiation in Bacteria: Insights from Studying Vibrio cholerae Chromosome 2.Microbiology and molecular biology reviews : MMBR · 2017Review
- Review
- Role of Protein Phosphorylation in the Regulation of Cell Cycle and DNA-Related Processes in Bacteria.Frontiers in microbiology · 2016Review
- Mycobacterium tuberculosis oriC sequestration by MtrA response regulator.Molecular microbiology · 2015Article
- Structure and interactions of the Bacillus subtilis sporulation inhibitor of DNA replication, SirA, with domain I of DnaA.Molecular microbiology · 2014Article
- Fifty years after the replicon hypothesis: cell-specific master regulators as new players in chromosome replication control.Journal of bacteriology · 2014Review
- Maintenance of chromosome structure in Pseudomonas aeruginosa.FEMS microbiology letters · 2014Review
- oriC-encoded instructions for the initiation of bacterial chromosome replication.Frontiers in microbiology · 2014Review
- Phage 29 phi protein p1 promotes replication by associating with the FtsZ ring of the divisome in Bacillus subtilis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Comprehensive methylome characterization of Mycoplasma genitalium and Mycoplasma pneumoniae at single-base resolution.PLoS genetics · 2013Article
- DNA-binding determinants promoting NHEJ by human Polμ.Nucleic acids research · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor Spo0A is a master regulator for entry into sporulation in Bacillus subtilis and also regulates expression of the virulent B. subtilis phage phi29. Here, we describe a novel function for Spo0A, being an inhibitor of DNA replication of both, the phi29 genome and the B. subtilis chromosome. Binding of Spo0A near the phi29 DNA ends, constituting the two origins of replication of the linear phi29 genome, prevents formation of phi29 protein p6-nucleoprotein initiation complex resulting in inhibition of phi29 DNA replication. At the B. subtilis oriC, binding of Spo0A to specific sequences, which mostly coincide with DnaA-binding sites, prevents open complex formation. Thus, by binding to the origins of replication, Spo0A prevents the initiation step of DNA replication of either genome. The implications of this novel role of Spo0A for phage phi29 development and the bacterial chromosome replication during the onset of sporulation are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.