SynthesisLeukemia2006
Loss of antibodies and response to (re-)vaccination in children after treatment for acute lymphocytic leukemia: a systematic review.
Synthesis in Leukemia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 113 citations in OpenAlex.
- Phase II Study of Responses to Vaccination in Pediatric Cancer Survivors Following Standard-of-Care Non-HSCT Chemotherapy.Pediatric blood & cancer · 2025Trial
- Immunologic effects of hydroxyurea in sickle cell anemia.Pediatrics · 2014Trial
- Trial
- Vaccine-Induced Immunity in Children and Adolescents After Chemotherapy for Acute Lymphoblastic Leukemia: A Systematic Review.Vaccines · 2026Review
- Immunization coverage for children with cancer in Latin America and the Caribbean can be improved through strategic coordination of existing global agendas.Human vaccines & immunotherapeutics · 2025Article
- Immune Reconstitution and Need for Booster Vaccinations Among Non-Transplant Childhood Cancer Survivors: A Single-Center Experience.Cancer reports (Hoboken, N.J.) · 2025Article
- Serum Immunoglobulin Levels in Children with Acute Lymphoblastic Leukemia During Maintenance Chemotherapy and its Association with Severe Febrile Illness.Indian pediatrics · 2025Article
- Deficits in Long-Term Vaccine Immunity Among Childhood Cancer Survivors Despite Revaccination Programs.Vaccines · 2025Article
- Review
- Waning of Humoral Immunity to Vaccine-Preventable Diseases in Children Treated for Acute Lymphoblastic Leukemia: A Single-Center Retrospective Cross-Sectional AnalysisTurkish journal of haematology : official journal of Turkish Society of Haematology · 2024Article
- Antibody waning after immunosuppressive chemotherapy and immunomodulators, re-immunization considerations in pediatric patients with malignancy and chronic immune thrombocytopenic purpura.BMC infectious diseases · 2022Article
- Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.Neurology(R) neuroimmunology & neuroinflammation · 2022Review
- Molecular characterization of hepatitis B virus (HBV) isolated from a pediatric case of acute lymphoid leukemia, with a delayed response to antiviral treatment: a case report.BMC pediatrics · 2022Article
- Cutaneous diphtheria complicated oncologic reconstruction surgery in osteosarcoma.Clinical case reports · 2022Article
- Immunization status and re-immunization of childhood acute lymphoblastic leukemia survivors.Human vaccines & immunotherapeutics · 2021Article
- Immune function in childhood cancer survivors: a Children's Oncology Group review.The Lancet. Child & adolescent health · 2021Review
- Waning Vaccine Immunity and Vaccination Responses in Children Treated for Acute Lymphoblastic Leukemia: A Canadian Immunization Research Network Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Treatment and revaccination of children with paraneoplastic opsoclonus-myoclonus-ataxia syndrome and neuroblastoma: The Memorial Sloan Kettering experience.Pediatric blood & cancer · 2020Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intensified chemotherapy regimens resulting in improved survival of children with acute lymphocytic leukemia (ALL) lead to concerns about therapy-induced immune damage reflected by the loss of protection of previous immunizations and the efficacy of (re-)vaccination. The severity of secondary immunodeficiency, however, is not clear and knowledge is based on a limited number of studies. We performed a systematic review on literature concerning vaccination data of children with ALL published since 1980. Eight studies fulfilled the inclusion criteria. Regarding antibody titers after treatment, the number of children who had preserved the defined protection level for antibodies differed widely, ranging from 17 to 98% for diphtheria, 27 to 82% for Bordetella pertussis, 20 to 98% for tetanus, 62 to 100% for poliomyelitis, 35 to 100% for Haemophilus influenzae type B (HiB), 29 to 92% for mumps, 29 to 60% for measles and 72 to 92% for rubella. Most patients however responded to revaccination, demonstrating immunological recovery. Although the designs and results of the included studies varied widely, it can be concluded that cytostatic therapy for ALL in children results in a temporarily reduction of specific antibody levels. Memory is preserved but revaccination may be warranted. This is the first systematic review and the best possible current approximation of chemotherapy-induced immune damage in children after ALL treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.