ArticleLeukemia2006
Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in B-cell lineage malignancy identify a new breakpoint cluster region designated BVR2.
Article in Leukemia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Modeling tissue-specific breakpoint proximity of structural variations from whole-genomes to identify cancer drivers.Nature communications · 2022Article
- Article
- Burkitt lymphoma: interpreting FISH testing forBMJ case reports · 2022Article
- MYC break-apart FISH probe set reveals frequent unbalanced patterns of uncertain significance when evaluating aggressive B-cell lymphoma.Blood cancer journal · 2021Article
- Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution.Genes · 2021Review
- MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies.Journal of hematology & oncology · 2021Review
- Review
- Comparison Between Integrated Genomic DNA/RNA Profiling and Fluorescence In Situ Hybridization in the Detection of MYC, BCL-2, and BCL-6 Gene Rearrangements in Large B-Cell Lymphomas.American journal of clinical pathology · 2020Article
- False-negative rates forHaematologica · 2019Article
- Article
- High-resolution architecture and partner genes ofBlood advances · 2018Article
- Definition of MYC genetic heteroclonality in diffuse large B-cell lymphoma with 8q24 rearrangement and its impact on protein expression.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- Validation of break-apart and fusion MYC probes using a digital fluorescence in situ hybridization capture and imaging system.Journal of pathology informatics · 2016Article
- Article
- Atypical rearrangement involving 3'-IGH@ and a breakpoint at least 400 Kb upstream of an intact MYC in a CLL patient with an apparently balanced t(8;14)(q24.1;q32) and negative MYC expression.Molecular cytogenetics · 2013Article
- Article
- Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival.Blood · 2009Article
- Clinicopathologic features of CDK6 translocation-associated B-cell lymphoproliferative disorders.The American journal of surgical pathology · 2009Article
- Review
- The prevalence of IG translocations and 7q32 deletions in splenic marginal zone lymphoma.Leukemia · 2008Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Detection of translocations involving MYC at 8q24.1 in B-cell lineage malignancies (BCL) is important for diagnostic and prognostic purposes. However, routine detection of MYC translocations is often hampered by the wide variation in breakpoint location within the MYC region, particularly when a gene other than IGH, such as IGK or IGL, is involved. To address this issue, we developed and validated four fluorescence in situ hybridization (FISH) probes: two break apart probes to detect IGK and IGL translocations, and two dual-color, dual-fusion FISH (D-FISH) probes to detect IGK-MYC and IGL-MYC. MYC rearrangements (four IGK-MYC, 12 IGL-MYC and four unknown partner gene-MYC) were correctly identified in 20 of 20 archival BCL specimens known to have MYC rearrangements not involving IGH. Seven specimens, all of which lacked MYC rearrangements using a commercial IGH/MYC D-FISH probe, were found to have 8q24 breakpoints within a cluster region >350-645 kb 3' from MYC, provisionally designated as Burkitt variant rearrangement region 2 (BVR2). FISH is a useful ancillary tool in identifying MYC rearrangements. In light of the discovery of the distally located BVR2 breakpoint cluster region, it is important to use MYC FISH probes that cover a breakpoint region at least 1.0 Mb 3' of MYC.
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