ArticleGenetics2006
Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 156 citations in OpenAlex.
- Strain-dependent resistance of yellow mealworm (Coleoptera: Tenebrionidae) to bacterial infection with and without probiotic supplementation.Journal of economic entomology · 2026Article
- Non-additive transcriptional regulation underpins an additive survival trait in populations of Drosophila selected for increased post infection survival.BMC ecology and evolution · 2026Article
- Life-Stage-Dependent Variation in Gastrointestinal Microbial Communities of Drosophila melanogaster.Microbial ecology · 2026Article
- Ovariole number does not predict reproductive output or trade-off with immunity in Drosophila melanogaster.PloS one · 2025Article
- Experimental adaptation to singular pathogen challenge reduces susceptibility to novel pathogens inCurrent research in insect science · 2025Article
- Genetic Variation in Trophic Avoidance Behaviour Shows Fruit Flies are Generally Attracted to Bacterial Substrates.Ecology and evolution · 2024Article
- Transiently restricting individual amino acids protectsOpen biology · 2024Article
- High sugar diets can increase susceptibility to bacterial infection in Drosophila melanogaster.PLoS pathogens · 2024Article
- Idiosyncratic effects of bacterial infection on female fecundity inCurrent research in insect science · 2024Article
- Drosophila immune priming to Enterococcus faecalis relies on immune tolerance rather than resistance.PLoS pathogens · 2023Article
- High-throughput phenotyping of infection by diverse microsporidia species reveals a wild C. elegans strain with opposing resistance and susceptibility traits.PLoS pathogens · 2023Article
- Host's genetic background determines the outcome of reciprocal faecal transplantation on life-history traits and microbiome composition.Animal microbiome · 2022Article
- Article
- Decomposing virulence to understand bacterial clearance in persistent infections.Nature communications · 2022Article
- Host Resistance to Bacterial Infection Varies Over Time, but Is Not Affected by a Previous Exposure to the Same Pathogen.Frontiers in physiology · 2022Article
- Orally acquired cyclic dinucleotides drive dSTING-dependent antiviral immunity in enterocytes.Cell reports · 2021Article
- The molecular architecture of Drosophila melanogaster defense against Beauveria bassiana explored through evolve and resequence and quantitative trait locus mapping.G3 (Bethesda, Md.) · 2021Article
- Article
- A SNP assay for assessing diversity in immune genes in the honey bee (Apis mellifera L.).Scientific reports · 2021Article
- The mode of expression divergence inGenome research · 2021Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Insects use a generalized immune response to combat bacterial infection. We have previously noted that natural populations of D. melanogaster harbor substantial genetic variation for antibacterial immunocompetence and that much of this variation can be mapped to genes that are known to play direct roles in immunity. It was not known, however, whether the phenotypic effects of variation in these genes are general across the range of potentially infectious bacteria. To address this question, we have reinfected the same set of D. melanogaster lines with Serratia marcescens, the bacterium used in the previous study, and with three additional bacteria that were isolated from the hemolymph of wild-caught D. melanogaster. Two of the new bacteria, Enterococcus faecalis and Lactococcus lactis, are gram positive. The third, Providencia burhodogranaria, is gram negative like S. marcescens. Drosophila genotypes vary highly significantly in bacterial load sustained after infection with each of the four bacteria, but mean loads are largely uncorrelated across bacteria. We have tested statistical associations between immunity phenotypes and nucleotide polymorphism in 21 candidate immunity genes. We find that molecular variation in some genes, such as Tehao, contributes to phenotypic variation in the suppression of only a subset of the pathogens. Variation in SR-CII and 18-wheeler, however, has effects that are more general. Although markers in SR-CII and 18-wheeler explain >20% of the phenotypic variation in resistance to L. lactis and E. faecalis, respectively, most of the molecular polymorphisms tested explain <10% of the total variance in bacterial load sustained after infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.