ArticleGenetics2006
Zebrafish genomic instability mutants and cancer susceptibility.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 65 citations in OpenAlex.
- Driving precision medicine in testicular germ cell tumors: from preclinical models to clinical applications.Therapeutic advances in medical oncology · 2026Review
- Oxidative Stress Biomarkers in Fish Exposed to Environmental Concentrations of Pharmaceutical Pollutants: A Review.Biology · 2025Review
- Whole-organism 3D quantitative characterization of zebrafish melanin by silver deposition micro-CT.eLife · 2021Article
- Genetic Engineering of Zebrafish in Cancer Research.Cancers · 2020Review
- LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA.Nucleic acids research · 2018Article
- Review
- Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis.Oncotarget · 2016Article
- Whole-Organism Cellular Pathology: A Systems Approach to Phenomics.Advances in genetics · 2016Review
- Article
- Zebrafish cancer: the state of the art and the path forward.Nature reviews. Cancer · 2013Review
- Zebrafish models of human liver development and disease.Comprehensive Physiology · 2013Review
- Mutations in LRRC50 predispose zebrafish and humans to seminomas.PLoS genetics · 2013Article
- MMAPPR: mutation mapping analysis pipeline for pooled RNA-seq.Genome research · 2013Article
- Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genome.PLoS genetics · 2012Article
- Myelopoiesis and myeloid leukaemogenesis in the zebrafish.Advances in hematology · 2012Article
- Genome evolution and meiotic maps by massively parallel DNA sequencing: spotted gar, an outgroup for the teleost genome duplication.Genetics · 2011Article
- Use of RecA fusion proteins to induce genomic modifications in zebrafish.Nucleic acids research · 2011Article
- Transgenic expression of walleye dermal sarcoma virus rv-cyclin (orfA) in zebrafish does not result in tissue proliferation.Marine biotechnology (New York, N.Y.) · 2011Article
- Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish.PLoS genetics · 2011Article
- Zebrafish models of germ cell tumor.Methods in cell biology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Somatic loss of tumor suppressor gene function comprising the second hit of Knudson's two-hit hypothesis is important in human cancer. A genetic screen was performed in zebrafish (Danio rerio) to find mutations that cause genomic instability (gin), as scored by Streisinger's mosaic-eye assay that models this second hit. The assay, based on a visible test for loss of wild-type gene function at a single locus, golden, is representative of genomewide events. Twelve ENU-induced genomic instability (gin) mutations were isolated. Most mutations showed weak dominance in heterozygotes and all showed a stronger phenotype in homozygotes. Trans-heterozygosity for 7 of these mutations showed greatly enhanced instability. A variety of spontaneous tumors were found in heterozygous adults from all gin lines, consistent with the expectation that genomic instability (mutator) mutations can accelerate carcinogenesis. The incidence of spontaneous cancer at 30-34 months was increased 9.6-fold in heterozygotes for the mutant with the strongest phenotype, gin-10. Tumors were seen in skin, colon, kidney, liver, pancreas, ovary, testis, and neuronal tissues, with multiple tumors in some fish. The study of these mutants will add to our understanding of the mechanisms of somatic loss of gene function and how those mechanisms contribute to cancer susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.