ArticleGenetics2006
Cumulative effects of spontaneous mutations for fitness in Caenorhabditis: role of genotype, environment and stress.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed.
- High Rate of Mutation and Efficient Removal by Selection of Structural Variants From Natural Populations of Caenorhabditis Elegans.Genome biology and evolution · 2026Article
- Scaling the fitness effects of mutations with respect to differentially adapted Arabidopsis thaliana accessions under natural conditions.Evolution; international journal of organic evolution · 2025Article
- Heat tolerance and genetic adaptations in Caenorhabditis briggsae: insights from comparative studies with Caenorhabditis elegans.Genetics · 2025Article
- Article
- Temperature dependence of spontaneous mutation rates.Genome research · 2021Article
- Consequences of mutation accumulation for growth performance are more likely to be resource-dependent at higher temperatures.BMC ecology and evolution · 2021Article
- Fitness effects of spontaneous mutations in a warming world.Evolution; international journal of organic evolution · 2021Article
- Males, Outcrossing, and Sexual Selection inGenetics · 2019Review
- The mutational decay of male-male and hermaphrodite-hermaphrodite competitive fitness in the androdioecious nematode C. elegans.Heredity · 2018Article
- Fitness change in relation to mutation number in spontaneous mutation accumulation lines of Chlamydomonas reinhardtii.Evolution; international journal of organic evolution · 2017Article
- The mutational structure of metabolism in Caenorhabditis elegans.Evolution; international journal of organic evolution · 2016Article
- Mutation Is a Sufficient and Robust Predictor of Genetic Variation for Mitotic Spindle Traits in Caenorhabditis elegans.Genetics · 2016Article
- Fitness Effects of Spontaneous Mutations in Picoeukaryotic Marine Green Algae.G3 (Bethesda, Md.) · 2016Article
- Fitness effects of new mutations in Chlamydomonas reinhardtii across two stress gradients.Journal of evolutionary biology · 2016Article
- Article
- The red death meets the abdominal bristle: polygenic mutation for susceptibility to a bacterial pathogen in Caenorhabditis elegans.Evolution; international journal of organic evolution · 2015Article
- Dynamic epistasis under varying environmental perturbations.PloS one · 2015Article
- Mainstreaming Caenorhabditis elegans in experimental evolution.Proceedings. Biological sciences · 2014Review
- Temporal dynamics of outcrossing and host mortality rates in host-pathogen experimental coevolution.Evolution; international journal of organic evolution · 2013Article
- Invariance (?) of mutational parameters for relative fitness over 400 generations of mutation accumulation in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2012Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
It is often assumed that the mutation rate is an evolutionarily optimized property of a taxon. The relevant mutation rate is for mutations that affect fitness, U, but the strength of selection on the mutation rate depends on the average effect of a mutation. Determination of U is complicated by the possibility that mutational effects depend on the particular environmental context in which the organism exists. It has been suggested that the effects of deleterious mutations are typically magnified in stressful environments, but most studies confound genotype with environment, so it is unclear to what extent environmental specificity of mutations is specific to a particular starting genotype. We report a study designed to separate effects of species, genotype, and environment on the degradation of fitness resulting from new mutations. Mutations accumulated for >200 generations at 20 degrees in two strains of two species of nematodes that differ in thermal sensitivity. Caenorhabditis briggsae and C. elegans have similar demography at 20 degrees, but C. elegans suffers markedly reduced fitness at 25 degrees. We find little evidence that mutational properties differ depending on environmental conditions and mutational correlations between environments are close to those expected if effects were identical in both environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.