ArticleProceedings of the National Academy of Sciences of the United States of America2006
Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 79 citations in OpenAlex.
- Article
- CD47 stabilizes ROBO2 to regulate glioblastoma progression by preventing ITCH-mediated ubiquitination.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- trithorax is an essential regulator of cardiac Hox gene expression and anterior-posterior patterning of the Drosophila embryonic heart tube.Biology open · 2025Article
- TheeLife · 2025Article
- ThebioRxiv : the preprint server for biology · 2024Article
- Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates axon guidance genes in Drosophila.PloS one · 2024Article
- Expanding the phenome and variome of the ROBO-SLIT pathway in congenital heart defects: toward improving the genetic testing yield of CHD.Journal of translational medicine · 2023Article
- Article
- Cbl-Associated Protein CAP contributes to correct formation and robust function of the Drosophila heart tube.PloS one · 2020Article
- Slit-Robo signalling in heart development.Cardiovascular research · 2018Review
- Conserved signaling mechanisms in Drosophila heart development.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Review
- Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling.Nature communications · 2016Article
- On the Morphology of the Drosophila Heart.Journal of cardiovascular development and disease · 2016Review
- Square Cell Packing in the Drosophila Embryo through Spatiotemporally Regulated EGF Receptor Signaling.Developmental cell · 2015Article
- Article
- Cellular Mechanisms of Drosophila Heart Morphogenesis.Journal of cardiovascular development and disease · 2015Article
- The Unc-5 Receptor Is Directly Regulated by Tinman in the Developing Drosophila Dorsal Vessel.PloS one · 2015Article
- Cdc42 and formin activity control non-muscle myosin dynamics during Drosophila heart morphogenesis.The Journal of cell biology · 2014Article
- Distinct functions of the laminin β LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila.BMC developmental biology · 2014Article
- Methods to assess Drosophila heart development, function and aging.Methods (San Diego, Calif.) · 2014Review
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3 authors at 2 institutions in 1 country.
Funding
Abstract
Heart morphogenesis requires the coordinated regulation of cell movements and cell-cell interactions between distinct populations of cardiac precursor cells. Little is known about the mechanisms that organize cardiac cells into this complex structure. In this study, we analyzed the role of Slit, an extracellular matrix protein and its transmembrane receptors Roundabout (Robo) and Roundabout2 (Robo2) during morphogenesis of the Drosophila heart tube, a process analogous to early heart formation in vertebrates. During heart assembly, two types of progenitor cells align into rows and coordinately migrate to the dorsal midline of the embryo, where they merge to assemble a linear heart tube. Here we show that cardiac-specific expression of Slit is required to maintain adhesion between cells within each row during dorsal migration. Moreover, differential Robo expression determines the relative distance each row is positioned from the dorsal midline. The innermost CBs express only Robo, whereas the flanking pericardial cells express both receptors. Removal of robo2 causes pericardial cells to shift toward the midline, whereas ectopic robo2 in CBs drives them laterally, resulting in an unfused heart tube. We propose a model in which Slit has a dual role during assembly of the linear heart tube, functioning to regulate both cell positioning and adhesive interactions between migrating cardiac precursor cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.