ReviewThe Journal of physiology2006
Regulation of electromotility in the cochlear outer hair cell.
Review in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- L-Ergothioneine slows the progression of age-related hearing loss in CBA/CaJ mice.Hearing research · 2024Article
- Structural and functional diversity of mitochondria in vestibular/cochlear hair cells and vestibular calyx afferents.Hearing research · 2022Review
- Deletion of Oncomodulin Gives Rise to Early Progressive Cochlear Dysfunction in C57 and CBA Mice.Frontiers in aging neuroscience · 2021Article
- Inner Ear Connexin Channels: Roles in Development and Maintenance of Cochlear Function.Cold Spring Harbor perspectives in medicine · 2019Review
- 3D Ultrastructure of the Cochlear Outer Hair Cell Lateral Wall Revealed By Electron Tomography.Frontiers in cellular neuroscience · 2019Article
- Olivocochlear Efferents in Animals and Humans: From Anatomy to Clinical Relevance.Frontiers in neurology · 2018Review
- Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.Comprehensive Physiology · 2017Review
- Prestin regulation and function in residual outer hair cells after noise-induced hearing loss.PloS one · 2013Article
- Calcium signaling in the cochlea - Molecular mechanisms and physiopathological implications.Cell communication and signaling : CCS · 2012Article
- Computational modelling elucidates the mechanism of ciliary regulation in health and disease.BMC systems biology · 2011Article
- Oncomodulin identifies different hair cell types in the mammalian inner ear.The Journal of comparative neurology · 2010Article
- Interaction between CFTR and prestin (SLC26A5).Biochimica et biophysica acta · 2010Article
- The ultrastructural distribution of prestin in outer hair cells: a post-embedding immunogold investigation of low-frequency and high-frequency regions of the rat cochlea.The European journal of neuroscience · 2010Article
- Aquaporin-6 expression in the cochlear sensory epithelium is downregulated by salicylates.Journal of biomedicine & biotechnology · 2010Article
- Primary processes in sensory cells: current advances.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2009Review
- Human hereditary hearing impairment: mouse models can help to solve the puzzle.Human genetics · 2008Review
- Cochlear amplification, outer hair cells and prestin.Current opinion in neurobiology · 2008Review
- Controlled microaspiration for high-pressure freezing: a new method for ultrastructural preservation of fragile and sparse tissues for TEM and electron tomography.Journal of microscopy · 2008Article
- The cochlea--new insights into the conversion of sound into electrical signals.The Journal of physiology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanosensory outer hair cells play an essential role in the amplification of sound-induced vibrations within the mammalian cochlea due to their ability to contract or elongate following changes of the intracellular potential. This unique property of outer hair cells is known as electromotility. Selective efferent innervation of these cells within the organ of Corti suggests that regulation of outer hair cell electromotility may be the primary function of the efferent control in the cochlea. A number of studies demonstrate that outer hair cell electromotility is indeed modulated by the efferent neurotransmitter, acetylcholine. The effects of acetylcholine on outer hair cells include cell hyperpolarization and a decrease of the axial stiffness, both mediated by intracellular Ca(2+). This article reviews these results and considers other potential mechanisms that may regulate electromotility, such as direct modification of the plasma membrane molecular motors, alteration of intracellular pressure, and modification of intracellular chloride concentration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.