ArticleDevelopment (Cambridge, England)2006
Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium.
Article in Development (Cambridge, England), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- PI4P-mediated solid-like Merlin condensates orchestrate Hippo pathway regulation.Science (New York, N.Y.) · 2024Article
- Variants in CAPZA2, a member of an F-actin capping complex, cause intellectual disability and developmental delay.Human molecular genetics · 2020Article
- Upstream paths for Hippo signaling in Drosophila organ development.BMB reports · 2018Review
- MoCAP proteins regulated by MoArk1-mediated phosphorylation coordinate endocytosis and actin dynamics to govern development and virulence of Magnaporthe oryzae.PLoS genetics · 2017Article
- Twinstar/cofilin is required for regulation of epithelial integrity and tissue growth in Drosophila.Oncogene · 2016Article
- Identification and functional analysis of healing regulators in Drosophila.PLoS genetics · 2015Article
- Article
- Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels.PloS one · 2014Article
- Article
- Hippo signaling in Drosophila: recent advances and insights.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Review
- Cell competition and its implications for development and cancer.Journal of genetics and genomics = Yi chuan xue bao · 2011Review
- Modulating F-actin organization induces organ growth by affecting the Hippo pathway.The EMBO journal · 2011Article
- The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development.Development (Cambridge, England) · 2010Article
- Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane.The Journal of cell biology · 2010Article
- Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis.Developmental biology · 2009Article
- New insights into mechanism and regulation of actin capping protein.International review of cell and molecular biology · 2008Review
- The flare gene, which encodes the AIP1 protein of Drosophila, functions to regulate F-actin disassembly in pupal epidermal cells.Genetics · 2007Article
- Drosophila as a genetic and cellular model for studies on axonal growth.Neural development · 2007Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tissue patterning must be translated into morphogenesis through cell shape changes mediated by remodeling of the actin cytoskeleton. We have found that Capping protein alpha (Cpa) and Capping protein beta (Cpb), which prevent extension of the barbed ends of actin filaments, are specifically required in the wing blade primordium of the Drosophila wing disc. cpa or cpb mutant cells in this region, but not in the remainder of the wing disc, are extruded from the epithelium and undergo apoptosis. Excessive actin filament polymerization is not sufficient to explain this phenotype, as loss of Cofilin or Cyclase-associated protein does not cause cell extrusion or death. Misexpression of Vestigial, the transcription factor that specifies the wing blade, both increases cpa transcription and makes cells dependent on cpa for their maintenance in the epithelium. Our results suggest that Vestigial specifies the cytoskeletal changes that lead to morphogenesis of the adult wing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.