ArticleBehavioral and brain functions : BBF2006
The IMAGE project: methodological issues for the molecular genetic analysis of ADHD.
Article in Behavioral and brain functions : BBF, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Electrophysiological markers of genetic risk for attention deficit hyperactivity disorder.Expert reviews in molecular medicine · 2011Pooled it
- Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies.Journal of psychiatry & neuroscience : JPN · 2009Pooled it
- Independent oscillatory patterns determine performance fluctuations in children with attention deficit/hyperactivity disorder.Brain : a journal of neurology · 2011Trial
- Boys Score Higher Everywhere? Gender Differences in Parent-Reported ADHD Symptoms Across Age Groups and Four Countries.Child psychiatry and human development · 2026Article
- The Etiological and Predictive Association Between ADHD and Cognitive Performance From Childhood to Young Adulthood.Journal of attention disorders · 2023Article
- Male-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain.Child and adolescent psychiatry and mental health · 2023Article
- Individual differences in sensitivity to positive home environment among children "at risk" for attention-deficit/hyperactivity disorder: A review.Frontiers in psychiatry · 2022Review
- ADHD and reification: Four ways a psychiatric construct is portrayed as a disease.Frontiers in psychiatry · 2022Article
- Test-Retest Reliability and Measurement Invariance of Executive Function Tasks in Young Children With and Without ADHD.Journal of attention disorders · 2020Article
- KTN1 variants and risk for attention deficit hyperactivity disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020Article
- Relationship between Health-Related Quality of Life and Physical Activity in Children with Hyperactivity.International journal of environmental research and public health · 2020Article
- Genomic evidence for MHC disassortative mating in humans.Proceedings. Biological sciences · 2019Article
- A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder.Molecular psychiatry · 2018Article
- A new mouse model of ADHD for medication development.Scientific reports · 2016Article
- Transactional relations between caregiving stress, executive functioning, and problem behavior from early childhood to early adolescence.Development and psychopathology · 2016Article
- A decade of contributions to understanding and ameliorating attention deficit-hyperactivity disorder.Behavioral and brain functions : BBF · 2016Review
- Childhood predictors of adolescent and young adult outcome in ADHD.Journal of psychiatric research · 2015Article
- Duplications in ADHD patients harbour neurobehavioural genes that are co-expressed with genes associated with hyperactivity in the mouse.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015Article
- Genome-wide pathway analysis in attention-deficit/hyperactivity disorder.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- Quantitative linkage for autism spectrum disorders symptoms in attention-deficit/hyperactivity disorder: significant locus on chromosome 7q11.Journal of autism and developmental disorders · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The genetic mechanisms involved in attention deficit hyperactivity disorder (ADHD) are being studied with considerable success by several centres worldwide. These studies confirm prior hypotheses about the role of genetic variation within genes involved in the regulation of dopamine, norepinephrine and serotonin neurotransmission in susceptibility to ADHD. Despite the importance of these findings, uncertainties remain due to the very small effects sizes that are observed. We discuss possible reasons for why the true strength of the associations may have been underestimated in research to date, considering the effects of linkage disequilibrium, allelic heterogeneity, population differences and gene by environment interactions. With the identification of genes associated with ADHD, the goal of ADHD genetics is now shifting from gene discovery towards gene functionality--the study of intermediate phenotypes ('endophenotypes'). We discuss methodological issues relating to quantitative genetic data from twin and family studies on candidate endophenotypes and how such data can inform attempts to link molecular genetic data to cognitive, affective and motivational processes in ADHD. The International Multi-centre ADHD Gene (IMAGE) project exemplifies current collaborative research efforts on the genetics of ADHD. This European multi-site project is well placed to take advantage of the resources that are emerging following the sequencing of the human genome and the development of international resources for whole genome association analysis. As a result of IMAGE and other molecular genetic investigations of ADHD, we envisage a rapid increase in the number of identified genetic variants and the promise of identifying novel gene systems that we are not currently investigating, opening further doors in the study of gene functionality.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.