ArticleAnimal genetics2006
Novel integrative genomics strategies to identify genes for complex traits.
Article in Animal genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dissecting Complex and Multifactorial Nature of Alzheimer's Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective.Molecular neurobiology · 2016Pooled it
- Omics Application in Animal Science-A Special Emphasis on Stress Response and Damaging Behaviour in Pigs.Genes · 2020Review
- How powerful are summary-based methods for identifying expression-trait associations under different genetic architectures?Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2018Article
- An Integrative Genomic Study Implicates the Postsynaptic Density in the Pathogenesis of Bipolar Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes.Genes & nutrition · 2015Article
- Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection.PLoS genetics · 2015Article
- Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Article
- Integrative systems biology approaches in asthma pharmacogenomics.Pharmacogenomics · 2012Review
- Article
- Using the BITOLA system to identify candidate genes for Parkinson's disease.Bosnian journal of basic medical sciences · 2011Article
- Database of cattle candidate genes and genetic markers for milk production and mastitis.Animal genetics · 2009Article
- Article
- A systematic strategy for large-scale analysis of genotype phenotype correlations: identification of candidate genes involved in African trypanosomiasis.Nucleic acids research · 2007Article
- Convergent Functional Genomics of bipolar disorder: from animal model pharmacogenomics to human genetics and biomarkers.Neuroscience and biobehavioral reviews · 2007Review
- ANEXdb: an integrated animal ANnotation and microarray EXpression database.Mammalian genome : official journal of the International Mammalian Genome SocietyArticle
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Abstract
Forward genetics is a common approach to dissecting complex traits like common human diseases. The ultimate aim of this approach was the identification of genes that are causal for disease or other phenotypes of interest. However, the forward genetics approach is by definition restricted to the identification of genes that have incurred mutations over the course of evolution or that incurred mutations as a result of chemical mutagenesis, and that as a result lead to disease or to variations in other phenotypes of interest. Genes that harbour no such mutations, but that play key roles in parts of the biological network that lead to disease, are systematically missed by this class of approaches. Recently, a class of novel integrative genomics approaches has been devised to elucidate the complexity of common human diseases by intersecting genotypic, molecular profiling, and clinical data in segregating populations. These novel approaches take a more holistic view of biological systems and leverage the vast network of gene-gene interactions, in combination with DNA variation data, to establish causal relationships among molecular profiling traits and between molecular profiling and disease (or other classic phenotypes). A number of novel genes for disease phenotypes have been identified as a result of these approaches, highlighting the utility of integrating orthogonal sources of data to get at the underlying causes of disease.
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