ArticleThe Clinical biochemist. Reviews2006
Normal iron metabolism and the pathophysiology of iron overload disorders.
Article in The Clinical biochemist. Reviews, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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Who cites it
43 citing papers in PubMed.
- Revisiting Congenital Atransferrinemia: A Rare but Treatable Cause of Pediatric Heart Failure.Cardiovascular & hematological disorders drug targets · 2026Review
- Estimated T50 calciprotein crystallization test in patients undergoing hemodialysis: Osaka Dialysis Complication Study (ODCS).Clinical and experimental nephrology · 2025Observational
- Ferroptosis: a novel pathway in the pathogenesis and treatment of endometriosis.Journal of molecular histology · 2025Review
- Effects of iron accumulation and its chelation on oxidative stress in intracortical implants.Acta biomaterialia · 2025Article
- Quantification of liver iron overload among pediatric patients with magnetic resonance imaging: current state of the art.Polish journal of radiology · 2025Review
- The Iron Enigma: Expounding Iron Deficiency in a Pregnant Woman With Hemochromatosis and Celiac Disease.Cureus · 2024Article
- Supplementation of Micro- and Macronutrients-A Role of Nutritional Status in Non-Alcoholic Fatty Liver Disease.International journal of molecular sciences · 2024Review
- Iron overload in anaemia with underlying haemoglobin constant spring in an antenatal mother in primary care.BMJ case reports · 2024Article
- HIV-Infected Patients as a Model of Aging.Microbiology spectrum · 2023Article
- Iron and Ferroptosis More than a Suspect: Beyond the Most Common Mechanisms of Neurodegeneration for New Therapeutic Approaches to Cognitive Decline and Dementia.International journal of molecular sciences · 2023Review
- Unscrambling the Role of Redox-Active Biometals in Dopaminergic Neuronal Death and Promising Metal Chelation-Based Therapy for Parkinson's Disease.International journal of molecular sciences · 2023Review
- Case report: Ultrasonographic and computed tomographic imaging features of hemochromatosis in a dog.Frontiers in veterinary science · 2023Article
- Transfusion burden in early childhood plays an important role in iron overload in Diamond-Blackfan anaemia.EJHaem · 2022Article
- Total Iron Concentrations in Different Biological Matrices-Influence of Physical Training.Nutrients · 2022Article
- Iron overload in alcoholic liver disease: underlying mechanisms, detrimental effects, and potential therapeutic targets.Cellular and molecular life sciences : CMLS · 2022Review
- Iron Deficiency in Heart Failure with Reduced Ejection Fraction: Pathophysiology, Diagnosis and Treatment.Arquivos brasileiros de cardiologia · 2022Review
- Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive autoimmune hepatitis.BMC gastroenterology · 2022Article
- Chronic Heart Failure: Clinical Implications of Iron Homeostasis Disturbances Revisited.Cureus · 2022Review
- Runx3 regulates iron metabolism via modulation of BMP signalling.Cell proliferation · 2021Article
- Hyperferritinemia-A Clinical Overview.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron overload disorders represent a heterogenous group of conditions resulting from inherited and acquired causes. If undiagnosed they can be progressive and fatal. Early detection and phlebotomy prior to the onset of cirrhosis can reduce morbidity and normalise life expectancy. We now have greater insight into the complex mechanisms of normal and disordered iron homeostasis following the discovery of new proteins and genetic defects. Here we review the normal mechanisms and regulation of gastrointestinal iron absorption and liver iron transport and their dysregulation in iron overload states. Advances in the understanding of the natural history of iron overload disorders and new methods for clinical detection and management of hereditary haemochromatosis are also reviewed. The current screening strategies target high-risk groups such as first-degree relatives of affected individuals and those with clinical features suggestive of iron loading. Potential ethical, legal and psychosocial issues arising through application of genetic screening programs need to be resolved prior to implementation of general population screening programs.
Identifiers
16886043PMC1390789What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.