ArticleJournal of bacteriology2006
Paired-end sequence mapping detects extensive genomic rearrangement and translocation during divergence of Francisella tularensis subsp. tularensis and Francisella tularensis subsp. holarctica populations.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Using affinity propagation clustering for identifying bacterial clades and subclades with whole-genome sequences of Francisella tularensis.PLoS neglected tropical diseases · 2020Article
- Two-Component Systems inFrontiers in cellular and infection microbiology · 2019Review
- Dynamics of copy number variation in host races of the pea aphid.Molecular biology and evolution · 2015Article
- Francisella tularensis Subtype A.II Genomic Plasticity in Comparison with Subtype A.I.PloS one · 2014Article
- Francisella tularensis molecular typing using differential insertion sequence amplification.Journal of clinical microbiology · 2011Article
- Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia.BMC microbiology · 2011Article
- Principles and challenges of genomewide DNA methylation analysis.Nature reviews. Genetics · 2010Review
- Article
- Molecular evolutionary consequences of niche restriction in Francisella tularensis, a facultative intracellular pathogen.PLoS pathogens · 2009Article
- Phylogeography of Francisella tularensis: global expansion of a highly fit clone.Journal of bacteriology · 2009Article
- Article
- Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula.Applied and environmental microbiology · 2007Article
- Identification of Francisella tularensis Himar1-based transposon mutants defective for replication in macrophages.Infection and immunity · 2007Article
- Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains.Genome biology · 2007Article
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6 authors.
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Abstract
Comparative genome hybridization of the Francisella tularensis subsp. tularensis and F. tularensis subsp. holarctica populations have shown that genome content is highly conserved, with relatively few genes in the F. tularensis subsp. tularensis genome being absent in other F. tularensis subspecies. To determine if organization of the genome differs between global populations of F. tularensis subsp. tularensis and F. tularensis subsp. holarctica, we have used paired-end sequence mapping (PESM) to identify regions of the genome where synteny is broken. The PESM approach compares the physical distances between paired-end sequencing reads of a library of a wild-type reference F. tularensis subsp. holarctica strain to the predicted lengths between the reads based on map coordinates of two different F. tularensis genome sequences. A total of 17 different continuous regions were identified in the F. tularensis subsp. holarctica genome (CR(holar)(c)(tica)) which are noncontiguous in the F. tularensis subsp. tularensis genome. Six of the 17 different CR(holarctica) are positioned as adjacent pairs in the F. tularensis subsp. tularensis genome sequence but are translocated in F. tularensis subsp. holarctica, implying that their arrangements are ancestral in F. tularensis subsp. tularensis and derived in F. tularensis subsp. holarctica. PCR analysis of the CR(holarctica) in 88 additional F. tularensis subsp. tularensis and F. tularensis subsp. holarctica isolates showed that the arrangements of the CR(holarctica) are highly conserved, particularly in F. tularensis subsp. holarctica, consistent with the hypothesis that global populations of F. tularensis subsp. holarctica have recently experienced a periodic selection event or they have emerged from a recent clonal expansion. Two unique F. tularensis subsp. tularensis-like strains were also observed which likely are derived from evolutionary intermediates and may represent a new taxonomic unit.
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