ArticleJournal of bacteriology2006
Cross-functionality of nitrogenase components NifH1 and VnfH in Anabaena variabilis.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Comparative genomic insights into culturable symbiotic cyanobacteria from the water fernMicrobial genomics · 2021Article
- Article
- Complete Genomes of Symbiotic Cyanobacteria Clarify the Evolution of Vanadium-Nitrogenase.Genome biology and evolution · 2019Article
- Metalloproteins in the Biology of Heterocysts.Life (Basel, Switzerland) · 2019Review
- Role of the nifB1 and nifB2 Promoters in Cell-Type-Specific Expression of Two Mo Nitrogenases in the Cyanobacterium Anabaena variabilis ATCC 29413.Journal of bacteriology · 2017Article
- Cyanobacterial nitrogenases: phylogenetic diversity, regulation and functional predictions.Genetics and molecular biology · 2017Article
- Role of RNA secondary structure and processing in stability of the nifH1 transcript in the cyanobacterium Anabaena variabilis.Journal of bacteriology · 2015Article
- Regulation of Three Nitrogenase Gene Clusters in the Cyanobacterium Anabaena variabilis ATCC 29413.Life (Basel, Switzerland) · 2014Review
- Regulation of nitrogenase gene expression by transcript stability in the cyanobacterium Anabaena variabilis.Journal of bacteriology · 2014Article
- Complete genome sequence of Anabaena variabilis ATCC 29413.Standards in genomic sciences · 2014Article
- Nitrogen fixation and hydrogen metabolism in cyanobacteria.Microbiology and molecular biology reviews : MMBR · 2010Review
- RNA processing of nitrogenase transcripts in the cyanobacterium Anabaena variabilis.Journal of bacteriology · 2010Article
- Cyanobacterial heterocysts.Cold Spring Harbor perspectives in biology · 2010Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anabaena variabilis fixes nitrogen under aerobic growth conditions in differentiated cells called heterocysts using either a Mo nitrogenase or a V nitrogenase. The nifH1 gene, which encodes the dinitrogenase reductase of the Mo nitrogenase that is expressed only in heterocysts, is cotranscribed with nifD1 and nifK1, which together encode the Mo dinitrogenase. These genes were expressed in the presence or absence of molybdate or vanadate. The vnfH gene, which encodes the dinitrogenase reductase of the V nitrogenase, was located about 23 kb from vnfDGK, which encodes the V dinitrogenase; however, like vnfDGK, vnfH was expressed only in the absence of molybdate, with or without vanadate. Like nifH1, the vnfH gene was expressed exclusively in heterocysts under either aerobic or anaerobic growth conditions and thus is under the control of developmental factors. The vnfH mutant was able to grow diazotrophically using the V nitrogenase, because NifH1, which was also made in cells starved for molybdate, could substitute for VnfH. Under oxic conditions, the nifH1 mutant grew in the absence of molybdate but not in its presence, using VnfH, while the nifH1 vnfH double mutant did not grow diazotrophically with or without molybdate or vanadate. A nifH1 mutant that expressed nifDK and vnfH but not vnfDGK was able to grow and fix nitrogen normally, indicating that VnfH could substitute for NifH in the Mo nitrogenase and that these dinitrogenase reductases are not involved in determining the metal specificity of the Mo nitrogenase or the V nitrogenase.
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