ArticleMolecular biology of the cell2006
Shiga toxin facilitates its retrograde transport by modifying microtubule dynamics.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- The Fatal Role of Enterohaemorrhagic Escherichia coli Shiga Toxin-associated Extracellular Vesicles in Host Cells.Journal of microbiology (Seoul, Korea) · 2023Review
- Rab11 endosomes and Pericentrin coordinate centrosome movement during pre-abscission in vivo.Life science alliance · 2022Article
- Cholera Toxin as a Probe for Membrane Biology.Toxins · 2021Review
- Molecular Biology ofToxins · 2020Review
- Targeting the Early Endosome-to-Golgi Transport of Shiga Toxins as a Therapeutic Strategy.Toxins · 2020Review
- Cytokinetic bridge triggers de novo lumen formation in vivo.Nature communications · 2020Article
- Review
- Protection against Shiga Toxins.Toxins · 2017Review
- Article
- Microtubule motors power plasma membrane tubulation in clathrin-independent endocytosis.Traffic (Copenhagen, Denmark) · 2015Article
- Article
- Rab11 endosomes contribute to mitotic spindle organization and orientation.Developmental cell · 2014Article
- Retrograde trafficking of AB₅ toxins: mechanisms to therapeutics.Journal of molecular medicine (Berlin, Germany) · 2013Review
- Cdc42 regulates microtubule-dependent Golgi positioning.Traffic (Copenhagen, Denmark) · 2010Article
- Shiga toxins--from cell biology to biomedical applications.Nature reviews. Microbiology · 2010Review
- The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.The Journal of cell biology · 2010Article
- Retrograde Shiga toxin trafficking is regulated by ARHGAP21 and Cdc42.Molecular biology of the cell · 2009Article
- In vitro intracellular trafficking of virulence antigen during infection by Yersinia pestis.PloS one · 2009Article
- Shiga toxin 2 affects the central nervous system through receptor globotriaosylceramide localized to neurons.The Journal of infectious diseases · 2008Article
- Multivesicular bodies: co-ordinated progression to maturity.Current opinion in cell biology · 2008Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The bacterial exotoxin Shiga toxin is endocytosed by mammalian host cells and transported retrogradely through the secretory pathway before entering the cytosol. Shiga toxin also increases the levels of microfilaments and microtubules (MTs) upon binding to the cell surface. The purpose for this alteration in cytoskeletal dynamics is unknown. We have investigated whether Shiga toxin-induced changes in MT levels facilitate its intracellular transport. We have tested the effects of the Shiga toxin B subunit (STB) on MT-dependent and -independent transport steps. STB increases the rate of MT-dependent Golgi stack repositioning after nocodazole treatment. It also enhances the MT-dependent accumulation of transferrin in a perinuclear recycling compartment. By contrast, the rate of MT-independent transferrin recycling is not significantly different when STB is present. We found that STB normally requires MTs and dynein for its retrograde transport to the juxtanuclear Golgi complex and that STB increases MT assembly. Furthermore, we find that MT polymerization is limiting for STB transport in cells. These results show that STB-induced changes in cytoskeletal dynamics influence intracellular transport. We conclude that the increased rate of MT assembly upon Shiga toxin binding facilitates the retrograde transport of the toxin through the secretory pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.