ArticleNucleic acids research2006
Carbon nanotubes selective destabilization of duplex and triplex DNA and inducing B-A transition in solution.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 122 citations in OpenAlex.
- Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?Nanomaterials (Basel, Switzerland) · 2022Review
- Carbon Nanotubes as Carriers in Drug Delivery for Non-Small Cell Lung Cancer, Mechanistic Analysis of Their Carcinogenic Potential, Safety Profiling and Identification of Biomarkers.International journal of nanomedicine · 2022Review
- Plasma-initiated graft polymerization of carbon nanoparticles as nano-based drug delivery systems.Biofouling · 2022Article
- Microtubule cytoskeleton-disrupting activity of MWCNTs: applications in cancer treatment.Journal of nanobiotechnology · 2020Review
- Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells.Particle and fibre toxicology · 2019Article
- Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans.Critical reviews in toxicology · 2017Review
- Cytogenetic evaluation of functionalized single-walled carbon nanotube in mice bone marrow cells.Environmental toxicology · 2016Article
- Carcinogenic Potential of High Aspect Ratio Carbon Nanomaterials.Environmental science. Nano · 2016Article
- Selective assembly of DNA-conjugated single-walled carbon nanotubes from the vascular secretome.ACS nano · 2014Article
- Chemical basis of interactions between engineered nanoparticles and biological systems.Chemical reviews · 2014Review
- Genotoxicity of multi-walled carbon nanotubes at occupationally relevant doses.Particle and fibre toxicology · 2014Article
- Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Chronic exposure to carbon nanotubes induces invasion of human mesothelial cells through matrix metalloproteinase-2.ACS nano · 2013Article
- Lighting up left-handed Z-DNA: photoluminescent carbon dots induce DNA B to Z transition and perform DNA logic operations.Nucleic acids research · 2013Article
- Contrasting enantioselective DNA preference: chiral helical macrocyclic lanthanide complex binding to DNA.Nucleic acids research · 2012Article
- Single-walled carbon nanotube-induced mitotic disruption.Mutation research · 2012Article
- Insights into the biomedical effects of carboxylated single-wall carbon nanotubes on telomerase and telomeres.Nature communications · 2012Article
- Stabilization of unstable CGC+ triplex DNA by single-walled carbon nanotubes under physiological conditions.Nucleic acids research · 2011Article
- Triplex inducer-directed self-assembly of single-walled carbon nanotubes: a triplex DNA-based approach for controlled manipulation of nanostructures.Nucleic acids research · 2011Article
- Genotoxicity of carbon nanofibers: are they potentially more or less dangerous than carbon nanotubes or asbestos?Toxicology and applied pharmacology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single-walled carbon nanotubes (SWNTs) have been considered as the leading candidate for nanodevice applications ranging from gene therapy and novel drug delivery to membrane separations. The miniaturization of DNA-nanotube devices for biological applications requires fully understanding DNA-nanotube interaction mechanism. We report here, for the first time, that DNA destabilization and conformational transition induced by SWNTs are sequence-dependent. Contrasting changes for SWNTs binding to poly[dGdC]:poly[dGdC] and poly[dAdT]:poly[dAdT] were observed. For GC homopolymer, DNA melting temperature was decreased 40 degrees C by SWNTs but no change for AT-DNA. SWNTs can induce B-A transition for GC-DNA but AT-DNA resisted the transition. Our circular dichroism, competitive binding assay and triplex destabilization studies provide direct evidence that SWNTs induce DNA B-A transition in solution and they bind to the DNA major groove with GC preference.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.