ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Slit proteins regulate distinct aspects of retinal ganglion cell axon guidance within dorsal and ventral retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 68 citations in OpenAlex.
- Extrinsic Regulation of Optic Nerve Axon Regeneration in the Adult Central Nervous System.Cells · 2026Review
- Human Retinal Ganglion Cells Respond to Evolutionarily Conserved Chemotropic Cues for Intra Retinal Guidance and Regeneration.Stem cells (Dayton, Ohio) · 2023Article
- Slit-Robo expression in the leech nervous system: insights into eyespot evolution.Cell & bioscience · 2023Article
- Meis homeobox genes control progenitor competence in the retina.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Neuronal NADPH oxidase 2 regulates growth cone guidance downstream of slit2/robo2.Developmental neurobiology · 2021Article
- Revisiting the role of Dcc in visual system development with a novel eye clearing method.eLife · 2020Article
- Missense mutation in SLIT2 associated with congenital myopia, anisometropia, connective tissue abnormalities, and obesity.Orphanet journal of rare diseases · 2018Article
- F-spondin Is Essential for Maintaining Circadian Rhythms.Frontiers in neural circuits · 2018Article
- Effects of neuroactive agents on axonal growth and pathfinding of retinal ganglion cells generated from human stem cells.Scientific reports · 2017Article
- Article
- Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels.Development (Cambridge, England) · 2017Article
- Reconnecting Eye to Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis.Open biology · 2016Article
- Functional assembly of accessory optic system circuitry critical for compensatory eye movements.Neuron · 2015Article
- Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- NF-Protocadherin Regulates Retinal Ganglion Cell Axon Behaviour in the Developing Visual System.PloS one · 2015Article
- Connecting the retina to the brain.ASN neuro · 2014Review
- Nerve repulsion by the lens and cornea during cornea innervation is dependent on Robo-Slit signaling and diminishes with neuron age.Developmental biology · 2012Article
- Heparan sulfate regulates intraretinal axon pathfinding by retinal ganglion cells.Investigative ophthalmology & visual science · 2011Article
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4 authors at 1 institution in 1 country.
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Abstract
An early step in the formation of the optic pathway is the directed extension of retinal ganglion cell (RGC) axons into the optic fiber layer (OFL) of the retina in which they project toward the optic disc. Using analysis of knock-out mice and in vitro assays, we found that, in the mammalian retina, Slit1 and Slit2, known chemorepellents for RGC axons, regulate distinct aspects of intraretinal pathfinding in different regions of the retina. In ventral and, to a much lesser extent, dorsal retina, Slits help restrict RGC axons to the OFL. Additionally, within dorsal retina exclusively, Slit2 also regulates the initial polarity of outgrowth from recently differentiated RGCs located in the retinal periphery. This regional specificity occurs despite the fact that Slits are expressed throughout the retina, and both dorsal and ventral RGCs are responsive to Slits. The gross morphology and layering of the retina of the slit-deficient retinas is normal, demonstrating that these distinct guidance defects are not the result of changes in the organization of the tissue. Although displaced or disorganized, the aberrant axons within both dorsal and ventral retina exit the eye. We also have found that the lens, which because of its peripheral location within the developing eye is ideally located to influence the initial direction of RGC axon outgrowth, secretes Slit2, suggesting this is the source of Slit regulating OFL development. These data demonstrate clearly that multiple mechanisms exist in the retina for axon guidance of which Slits are an important component.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.