ArticleGenome biology2006
Primate-specific evolution of an LDLR enhancer.
Article in Genome biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Noncoding origins of anthropoid traits and a new null model of transposon functionalization.Genome research · 2014Article
- The common marmoset genome provides insight into primate biology and evolution.Nature genetics · 2014Article
- Active enhancer positions can be accurately predicted from chromatin marks and collective sequence motif data.BMC systems biology · 2013Article
- Functional primate genomics--leveraging the medical potential.Journal of molecular medicine (Berlin, Germany) · 2012Review
- MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.Blood · 2011Article
- Patterns of evolutionary constraints on genes in humans.BMC evolutionary biology · 2008Article
- Molecular population genetics of PCSK9: a signature of recent positive selection.Pharmacogenetics and genomics · 2008Article
- Multiple whole genome alignments and novel biomedical applications at the VISTA portal.Nucleic acids research · 2007Article
- Detection of weakly conserved ancestral mammalian regulatory sequences by primate comparisons.Genome biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundSequence changes in regulatory regions have often been invoked to explain phenotypic divergence among species, but molecular examples of this have been difficult to obtain.
resultsIn this study we identified an anthropoid primate-specific sequence element that contributed to the regulatory evolution of the low-density lipoprotein receptor. Using a combination of close and distant species genomic sequence comparisons coupled with in vivo and in vitro studies, we found that a functional cholesterol-sensing sequence motif arose and was fixed within a pre-existing enhancer in the common ancestor of anthropoid primates.
conclusionOur study demonstrates one molecular mechanism by which ancestral mammalian regulatory elements can evolve to perform new functions in the primate lineage leading to human.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.