ArticleMediators of inflammation2006
NKT cells in the induced sputum of severe asthmatics.
Article in Mediators of inflammation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- The Role of Innate T Cells in Inflammatory Disorders in Asthma and Chronic Rhinosinusitis.Clinical and experimental otorhinolaryngology · 2026Review
- Decoding innate lymphoid cells and innate-like lymphocytes in asthma: pathways to mechanisms and therapies.Journal of biomedical science · 2025Review
- Natural killer T cells in allergic asthma: implications for the development of novel immunotherapeutical strategies.Frontiers in immunology · 2024Review
- Article
- Innate-like Lymphocytes and Innate Lymphoid Cells in Asthma.Clinical reviews in allergy & immunology · 2020Review
- Measuring inflammation in paediatric severe asthma: biomarkers in clinical practice.Breathe (Sheffield, England) · 2020Review
- Development of Asthma in Inner-City Children: Possible Roles of MAIT Cells and Variation in the Home Environment.Journal of immunology (Baltimore, Md. : 1950) · 2018Observational
- Role of CD1d- and MR1-Restricted T Cells in Asthma.Frontiers in immunology · 2018Review
- The Role of Lipids in Development of Allergic Responses.Immune network · 2017Review
- NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma.PloS one · 2017Article
- β-Catenin is required for the differentiation of iNKT2 and iNKT17 cells that augment IL-25-dependent lung inflammation.BMC immunology · 2015Article
- Beneficial effects of sitostanol on the attenuated immune function in asthma patients: results of an in vitro approach.PloS one · 2012Article
- The split personality of NKT cells in malignancy, autoimmune and allergic disorders.Immunotherapy · 2011Review
- Harnessing regulatory T cells to suppress asthma: from potential to therapy.American journal of respiratory cell and molecular biology · 2010Review
- Chronic inflammation and asthma.Mutation research · 2010Review
- Natural killer T cells are not the predominant T cell in asthma and likely modulate, not cause, asthma.The Journal of allergy and clinical immunology · 2010Review
- Regulatory T cells in induced sputum of asthmatic children: association with inflammatory cytokines.Multidisciplinary respiratory medicine · 2010Article
- A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Recent advances in the role of NKT cells in allergic diseases and asthma.Current allergy and asthma reports · 2008Review
- Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17.The Journal of experimental medicine · 2008Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine whether there was a specific inflammatory process in severe asthmatics, the phenotypic characteristics of induced sputum immune cells were analysed among patients with severe asthma. Twenty-two induced sputa (10 severe asthmatics) were studied. Flow cytometric analysis was performed using immune cells of the sputum and monoclonal antibodies to CD3, CD4, CD8, CD56, CD25, and TCRgammadelta. The number of NKT (CD3(+) CD56(+)) cells was significantly higher in the sputum of severe asthmatics compared with mild asthmatic and healthy control groups (P < .05). CD8(+)CD56(+) cells were the predominant subtype of the increased NKT cells in severe asthmatics. CD3(+)CD56(+)Valpha24(+), TCRgammadelta(+) CD56(+), and CD4(+)CD25(+) T cells were significantly increased in severe asthmatic patients. These results suggest that the immunopathogenesis of severe asthmatics vary between severe and mild asthmatics, and that CD8(+)CD56(+) NKT cells may play an important role in the immunopathogenesis of severe asthma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.