ArticleGenes & development2006
E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.
Article in Genes & development, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Distinct leukemogenic mechanism of acute promyelocytic leukemia based on genomic structure of PML::RARα.Leukemia · 2025Article
- Transcription factor E4F1 as a regulator of cell life and disease progression.Science advances · 2023Review
- Transcription factor E4F1 dictates spermatogonial stem cell fate decisions by regulating mitochondrial functions and cell cycle progression.Cell & bioscience · 2023Article
- Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer.International journal of molecular sciences · 2022Article
- Bmi1 suppresses protein synthesis and promotes proteostasis in hematopoietic stem cells.Genes & development · 2022Article
- The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes.Nature communications · 2021Article
- Review
- E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice.Animals : an open access journal from MDPI · 2020Article
- Article
- Glucocorticoid Receptor Binding Inhibits an IntronicInternational journal of molecular sciences · 2018Article
- The Risk G Allele of the Single-Nucleotide Polymorphism rs928413 Creates a CREB1-Binding Site That ActivatesInternational journal of molecular sciences · 2018Article
- BMI1 reduces ATR activation and signalling caused by hydroxyurea.Oncotarget · 2017Article
- BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization.Nature communications · 2016Article
- E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The putative tumor suppressor gene EphA7 is a novel BMI-1 target.Oncotarget · 2016Article
- BMI1 Regulation of Self-Renewal and Multipotency in Human Mesenchymal Stem Cells.Current stem cell research & therapy · 2016Article
- Article
- UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.Blood · 2014Article
- Role of B lymphoma Mo-MLV insertion region 1 in the oncogenic behavior of retinoblastomas.Molecular vision · 2013Article
- It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53.Genes & cancer · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Polycomb group gene Bmi1 is essential for the proliferation of neural and hematopoietic stem cells. Much remains to be learned about the pathways involved in the severe hematopoietic phenotype observed in Bmi1 homozygous mutant mice except for the fact that loss of p53 or concomitant loss of p16(Ink4a) and p19(Arf) functions achieves only a partial rescue. Here we report the identification of E4F1, an inhibitor of cellular proliferation, as a novel BMI1-interacting partner in hematopoietic cells. We provide evidence that Bmi1 and E4f1 genetically interact in the hematopoietic compartment to regulate cellular proliferation. Most importantly, we demonstrate that reduction of E4f1 levels through RNA interference mediated knockdown is sufficient to rescue the clonogenic and repopulating ability of Bmi1(-/-) hematopoietic cells up to 3 mo post-transplantation. Using cell lines and MEF, we also demonstrate that INK4A/ARF and p53 are not essential for functional interaction between Bmi1 and E4f1. Together, these findings identify E4F1 as a key modulator of BMI1 activity in primitive hematopoietic cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.