ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Retrieval induces hippocampal-dependent reconsolidation of spatial memory.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Examining Adolescence as a Sensitive Period for High-Fat, High-Sugar Diet Exposure: A Systematic Review of the Animal Literature.Frontiers in neuroscience · 2019Pooled it
- PKMζ drives spatial memory reconsolidation but not maintenance.Frontiers in synaptic neuroscience · 2025Article
- Cannabinoid type 2 receptor deficiency leads to Aβ-induced cognitive impairment through promoting microglial sensitivity to Aβ in the prefrontal cortex in mice.IBRO neuroscience reports · 2024Article
- Learning without contingencies: A loss of synergy between memory and reward circuits in schizophrenia.Schizophrenia research · 2023Article
- Spatial contextual recognition memory updating is modulated by dopamine release in the dorsal hippocampus from the locus coeruleus.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Sex differences in acetylcholinesterase modulation during spatial and fear memory extinction in the amygdala; an animal study in the single prolonged stress model of PTSD.Research in pharmaceutical sciences · 2022Article
- Optogenetic inhibition of the dorsal hippocampus CA3 region during early-stage cocaine-memory reconsolidation disrupts subsequent context-induced cocaine seeking in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Nicotinic Acetylcholine Receptors Expressed by Striatal Interneurons Inhibit Striatal Activity and Control Striatal-Dependent Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Adult-born neurons immature during learning are necessary for remote memory reconsolidation in rats.Nature communications · 2021Article
- Molecular Mechanisms of Reconsolidation-Dependent Memory Updating.International journal of molecular sciences · 2020Review
- Behavioral tagging underlies memory reconsolidation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Effects of HDAC inhibitors on spatial memory and memory extinction in SPS-induced PTSD rats.Research in pharmaceutical sciences · 2020Article
- Early Cognitive Training Rescues Remote Spatial Memory but Reduces Cognitive Flexibility in Alzheimer's Disease Mice.Journal of Alzheimer's disease : JAD · 2020Article
- Recognition memory reconsolidation requires hippocampal Zif268.Scientific reports · 2019Article
- Influence of early stress on memory reconsolidation: Implications for post-traumatic stress disorder treatment.PloS one · 2018Article
- Naltrexone Facilitates Learning and Delays Extinction by Increasing AMPA Receptor Phosphorylation and Membrane Insertion.Biological psychiatry · 2016Article
- C3 deficiency ameliorates the negative effects of irradiation of the young brain on hippocampal development and learning.Oncotarget · 2016Article
- Behavioral alterations induced by repeated saxitoxin exposure in drinking water.The journal of venomous animals and toxins including tropical diseases · 2016Article
- Impaired causal awareness and associated cortical-basal ganglia structural changes in youth psychiatric disorders.NeuroImage. Clinical · 2016Article
- Characterization of spatial memory reconsolidation.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
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Authors and funding
5 authors.
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Abstract
Nonreinforced retrieval can cause extinction and/or reconsolidation, two processes that affect subsequent retrieval in opposite ways. Using the Morris water maze task we show that, in the rat, repeated nonreinforced expression of spatial memory causes extinction, which is unaffected by inhibition of protein synthesis within the CA1 region of the dorsal hippocampus. However, if the number of nonreinforced retrieval trials is insufficient to induce long-lasting extinction, then a hippocampal protein synthesis-dependent reconsolidation process recovers the original memory. Inhibition of hippocampal protein synthesis after reversal learning sessions impairs retention of the reversed preference and blocks persistence of the original one, suggesting that reversal learning involves reconsolidation rather than extinction of the original memory. Our results suggest the existence of a hippocampal protein synthesis-dependent reconsolidation process that operates to recover or update retrieval-weakened memories from incomplete extinction.
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