ArticleProceedings of the National Academy of Sciences of the United States of America2006
Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 78 citations in OpenAlex.
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- Paralog-Dependent Specialization of Paf1C Subunit, Ctr9, for Sex Chromosome Gene Regulation and Male Germline Differentiation in Drosophila.Genes to cells : devoted to molecular & cellular mechanisms · 2025Article
- Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress.Blood · 2023Article
- Rtf1 Transcriptionally Regulates Neonatal and Adult Cardiomyocyte Biology.Journal of cardiovascular development and disease · 2023Article
- Enhancing HIV-1 latency reversal through regulating the elongating RNA Pol II pause-release by a small-molecule disruptor of PAF1C.Science advances · 2023Article
- Day-night and seasonal variation of human gene expression across tissues.PLoS biology · 2023Article
- The PAF1 complex cell autonomously promotes oogenesis in Caenorhabditis elegans.Genes to cells : devoted to molecular & cellular mechanisms · 2022Article
- Day-night and seasonal variation of human gene expression across tissues.bioRxiv : the preprint server for biology · 2022Article
- The developmental origins of Notch-driven intrahepatic bile duct disorders.Disease models & mechanisms · 2021Article
- The Paf1 Complex: A Keystone of Nuclear Regulation Operating at the Interface of Transcription and Chromatin.Journal of molecular biology · 2021Review
- TheApplied and environmental microbiology · 2019Article
- PAF1 complex component Leo1 helps recruitProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Drosophila PAF1 Modulates PIWI/piRNA Silencing Capacity.Current biology : CB · 2017Article
- Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex.Nature communications · 2017Article
- Genome-wide SNP analysis using 2b-RAD sequencing identifies the candidate genes putatively associated with resistance to ivermectin in Haemonchus contortus.Parasites & vectors · 2017Article
- Drosophila CG2469 Encodes a Homolog of Human CTR9 and Is Essential for Development.G3 (Bethesda, Md.) · 2016Article
- Ctr9, a Key Component of the Paf1 Complex, Affects Proliferation and Terminal Differentiation in the Developing Drosophila Nervous System.G3 (Bethesda, Md.) · 2016Article
- An RNAi-Based Candidate Screen for Modifiers of the CHD1 Chromatin Remodeler and Assembly Factor in Drosophila melanogaster.G3 (Bethesda, Md.) · 2015Article
- Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex.Molecular and cellular biology · 2015Article
- Transcription-generated torsional stress destabilizes nucleosomes.Nature structural & molecular biology · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The Rtf1 subunit of the Paf1 complex is required for proper monoubiquitination of histone H2B and methylation of histone H3 on lysines 4 (H3K4) and 79 in yeast Saccharomyces cerevisiae. Using RNAi, we examined the role of Rtf1 in histone methylation and gene expression in Drosophila melanogaster. We show that Drosophila Rtf1 (dRtf1) is required for proper gene expression and development. Furthermore, we show that RNAi-mediated reduction of dRtf1 results in a reduction in histone H3K4 trimethylation levels on bulk histones and chromosomes in vivo, indicating that the histone modification pathway via Rtf1 is conserved among yeast, Drosophila, and human. Recently, it was demonstrated that histone H3K4 methylation mediated via the E3 ligase Bre1 is critical for transcription of Notch target genes in Drosophila. Here we demonstrate that the dRtf1 component of the Paf1 complex functions in Notch signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.