ArticleEnvironmental health perspectives2006
Di-(2-ethylhexyl) phthalate enhances atopic dermatitis-like skin lesions in mice.
Article in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 92 citations in OpenAlex.
- Atopic Dermatitis and Autism Spectrum Disorders: Common Role of Environmental and Clinical Co-Factors in the Onset and Severity of Their Clinical Course.International journal of molecular sciences · 2024Review
- Association between Urinary Phthalate Metabolite Concentration and Atopic Dermatitis in Korean Adolescents Participating in the Third Korean National Environmental Health Survey, 2015-2017.International journal of environmental research and public health · 2021Article
- Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact.International journal of environmental research and public health · 2020Review
- Environmental pollution and allergies.Journal of toxicologic pathology · 2017Review
- Exposure to phthalates and bisphenol A are associated with atopic dermatitis symptoms in children: a time-series analysis.Environmental health : a global access science source · 2017Article
- Elements of kitchen toxicology to exploit the value of traditional (African) recipes: The case ofToxicology reports · 2017Article
- Endocrine-disrupting chemicals and skin manifestations.Reviews in endocrine & metabolic disorders · 2016Review
- Phthalate Metabolites, Consumer Habits and Health Effects.International journal of environmental research and public health · 2016Article
- Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment.Environmental health : a global access science source · 2015Review
- Effect of the hand antiseptic agents benzalkonium chloride, povidone-iodine, ethanol, and chlorhexidine gluconate on atopic dermatitis in NC/Nga mice.International journal of medical sciences · 2015Article
- Allergic sensitization and the environment: latest update.Current allergy and asthma reports · 2014Review
- T-helper type-2 contact hypersensitivity of Balb/c mice aggravated by dibutyl phthalate via long-term dermal exposure.PloS one · 2014Article
- Effects on the local immunity in the testis by exposure to di-(2-ethylhexyl) phthalate (DEHP) in mice.The Journal of reproduction and development · 2013Article
- Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.Endocrine reviews · 2012Review
- Di-(2-ethylhexyl) phthalate induces production of inflammatory molecules in human macrophages.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Effects of diisononyl phthalate on atopic dermatitis in vivo and immunologic responses in vitro.Environmental health perspectives · 2010Article
- A clash of old and new scientific concepts in toxicity, with important implications for public health.Environmental health perspectives · 2009Article
- Phthalate ester-induced thymic stromal lymphopoietin mediates allergic dermatitis in mice.Immunology · 2009Article
- Effects of maternal exposure to di-(2-ethylhexyl) phthalate during fetal and/or neonatal periods on atopic dermatitis in male offspring.Environmental health perspectives · 2008Article
- Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males.Environmental health perspectives · 2007Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Di-(2-ethylhexyl) phthalate (DEHP) has been widely used in polyvinyl chloride products and has become ubiquitous in the developed countries. DEHP reportedly displays an adjuvant effect on immunoglobulin production. However, it has not been elucidated whether DEHP is associated with the aggravation of atopic dermatitis. We investigated the effects of DEHP on atopic dermatitis-like skin lesions induced by mite allergen in NC/Nga mice. NC/Nga male mice were injected intradermally with mite allergen on their right ears. In the presence of allergen, DEHP (0, 0.8, 4, 20, or 100 microg) was administered by intraperitoneal injection. We evaluated clinical scores, ear thickening, histologic findings, and the protein expression of chemokines. Exposure to DEHP at a dose of 0.8-20 microg caused deterioration of atopic dermatitis-like skin lesions related to mite allergen; this was evident from macroscopic and microscopic examinations. Furthermore, these changes were consistent with the protein expression of proinflammatory molecules such as macrophage inflammatory protein-1alpha (MIP-1alpha) and eotaxin in the ear tissue in overall trend. In contrast, 100 microg DEHP did not show the enhancing effects. These results indicate that DEHP enhances atopic dermatitis-like skin lesions at hundred-fold lower levels than the no observed adverse effect level determined on histologic changes in the liver of rodents. DEHP could be at least partly responsible for the recent increase in atopic dermatitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.