ArticleEnvironmental health perspectives2006
Volatile organic compounds and pulmonary function in the Third National Health and Nutrition Examination Survey, 1988-1994.
Article in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Systematic Review of Potential Occupational Respiratory Hazards Exposure Among Sewage Workers.Frontiers in public health · 2021Pooled it
- Determinants of volatile organic compound exposure among children with bronchopulmonary dysplasia.Pediatric research · 2026Article
- Association Between Volatile Organic Compound Metabolites in Urine and Adult Lung Function: Evidence From NHANES 2011-2012.The clinical respiratory journal · 2026Article
- Systemic analysis of 1,4-dichlorobenzenes effects on lung adenocarcinoma environmental exposure and core target regulation prediction.Discover oncology · 2026Article
- Diminished lung function mediating the associations between blood levels of volatile organic compounds and respiratory morbidity and mortality.Scientific reports · 2025Article
- Exposure to volatile organic compounds and chronic respiratory disease mortality, a case-cohort study.Respiratory research · 2025Article
- Exhaled volatile organic compounds for diagnosis and monitoring of asthma.World journal of clinical cases · 2023Review
- Exposure to Crude Oil-Related Volatile Organic Compounds Associated with Lung Function Decline in a Longitudinal Panel of Children.International journal of environmental research and public health · 2022Article
- Associations between airborne crude oil chemicals and symptom-based asthma.Environment international · 2022Article
- Ethanol-based disinfectant sprays drive rapid changes in the chemical composition of indoor air in residential buildings.Journal of hazardous materials letters · 2021Article
- Respiratory health, pulmonary function and local engagement in urban communities near oil development.Environmental research · 2021Article
- Application of Metabolomics in Pediatric Asthma: Prediction, Diagnosis and Personalized Treatment.Metabolites · 2021Review
- Respiratory health effects of residential individual and cumulative risk factors in children living in two cities of the Pearl River Delta Region, China.Journal of thoracic disease · 2020Article
- Effects of indoor environment and lifestyle on respiratory health of children in Chongqing, China.Journal of thoracic disease · 2020Article
- Source-Specific Volatile Organic Compounds and Emergency Hospital Admissions for Cardiorespiratory Diseases.International journal of environmental research and public health · 2020Article
- Chemical profile andToxicology reports · 2019Article
- Characterization and cancer risk assessment of VOCs in home and school environments in gran La Plata, Argentina.Environmental science and pollution research international · 2018Article
- Environmental triggers of COPD symptoms: a case cross-over study.BMJ open respiratory research · 2017Article
- UNMIX Methods Applied to Characterize Sources of Volatile Organic Compounds in Toronto, Ontario.Toxics · 2016Article
- Exposure to volatile organic compounds in healthcare settings.Occupational and environmental medicine · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundVolatile organic compounds (VOCs) are present in much higher concentrations indoors, where people spend most of their time, than outdoors and may have adverse health effects. VOCs have been associated with respiratory symptoms, but few studies address objective respiratory end points such as pulmonary function. Blood levels of VOCs may be more indicative of personal exposures than are air concentrations; no studies have addressed their relationship with respiratory outcomes.
objectiveWe examined whether concentrations of 11 VOCs that were commonly identified in blood from a sample of the U.S. population were associated with pulmonary function.
methodsWe used data from 953 adult participants (20-59 years of age) in the Third National Health and Nutrition Examination Survey (1988-1994) who had VOC blood measures as well as pulmonary function measures. Linear regression models were used to evaluate the relationship between 11 VOCs and measures of pulmonary function.
resultsAfter adjustment for smoking, only 1,4-dichlorobenzene (1,4-DCB) was associated with reduced pulmonary function. Participants in the highest decile of 1,4-DCB concentration had decrements of -153 mL [95% confidence interval (CI) , -297 to -8] in forced expiratory volume in 1 sec and -346 mL/sec (95% CI, -667 to -24) in maximum mid-expiratory flow rate, compared with participants in the lowest decile.
conclusionsExposure to 1,4-DCB, a VOC related to the use of air fresheners, toilet bowl deodorants, and mothballs, at levels found in the U.S. general population, may result in reduced pulmonary function. This common exposure may have long-term adverse effects on respiratory health.
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