ArticleBMC genomics2006
High-resolution comparative mapping among man, cattle and mouse suggests a role for repeat sequences in mammalian genome evolution.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Random, fragile, or correlated: Mechanisms of synteny decay in mammals.bioRxiv : the preprint server for biology · 2025Article
- Dynamic alternative DNA structures in biology and disease.Nature reviews. Genetics · 2023Review
- Molecular Cytogenetics in Domestic Bovids: A Review.Animals : an open access journal from MDPI · 2023Review
- Recurrent erosion of COA1/MITRAC15 exemplifies conditional gene dispensability in oxidative phosphorylation.Scientific reports · 2021Article
- De novo whole-genome assembly and resequencing resources for the roan (Hippotragus equinus), an iconic African antelope.G3 (Bethesda, Md.) · 2021Article
- Of Men and Mice: Modeling the Fragile X Syndrome.Frontiers in molecular neuroscience · 2018Article
- Novel Insights into Chromosome Evolution in Birds, Archosaurs, and Reptiles.Genome biology and evolution · 2016Article
- A high resolution map of mammalian X chromosome fragile regions assessed by large-scale comparative genomics.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Insight into the karyotype evolution of brachypodium species using comparative chromosome barcoding.PloS one · 2014Article
- Article
- Testing chromosomal phylogenies and inversion breakpoint reuse in Drosophila. The martensis cluster revisited.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- Ancestral grass karyotype reconstruction unravels new mechanisms of genome shuffling as a source of plant evolution.Genome research · 2010Article
- FISH mapping in cattle (Bos taurus L.) is not yet out of fashion.Journal of applied genetics · 2010Article
- Every genome sequence needs a good map.Genome research · 2009Article
- Analysis of fine-scale mammalian evolutionary breakpoints provides new insight into their relation to genome organisation.BMC genomics · 2009Article
- Breakpoint regions and homologous synteny blocks in chromosomes have different evolutionary histories.Genome research · 2009Article
- A high resolution RH map of the bovine major histocompatibility complex.BMC genomics · 2009Article
- Expression and identification of folate-sensitive fragile sites in British Suffolk sheep (Ovis aries).Journal of genetics · 2008Article
- Genome-wide mapping and characterization of hypomethylated sites in human tissues and breast cancer cell lines.Genome research · 2008Article
- High resolution radiation hybrid maps of bovine chromosomes 19 and 29: comparison with the bovine genome sequence assembly.BMC genomics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComparative mapping provides new insights into the evolutionary history of genomes. In particular, recent studies in mammals have suggested a role for segmental duplication in genome evolution. In some species such as Drosophila or maize, transposable elements (TEs) have been shown to be involved in chromosomal rearrangements. In this work, we have explored the presence of interspersed repeats in regions of chromosomal rearrangements, using an updated high-resolution integrated comparative map among cattle, man and mouse.
resultsThe bovine, human and mouse comparative autosomal map has been constructed using data from bovine genetic and physical maps and from FISH-mapping studies. We confirm most previous results but also reveal some discrepancies. A total of 211 conserved segments have been identified between cattle and man, of which 33 are new segments and 72 correspond to extended, previously known segments. The resulting map covers 91% and 90% of the human and bovine genomes, respectively. Analysis of breakpoint regions revealed a high density of species-specific interspersed repeats in the human and mouse genomes.
conclusionAnalysis of the breakpoint regions has revealed specific repeat density patterns, suggesting that TEs may have played a significant role in chromosome evolution and genome plasticity. However, we cannot rule out that repeats and breakpoints accumulate independently in the few same regions where modifications are better tolerated. Likewise, we cannot ascertain whether increased TE density is the cause or the consequence of chromosome rearrangements. Nevertheless, the identification of high density repeat clusters combined with a well-documented repeat phylogeny should highlight probable breakpoints, and permit their precise dating. Combining new statistical models taking the present information into account should help reconstruct ancestral karyotypes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.