ArticleTraffic (Copenhagen, Denmark)2006
A phenotypic recessive, post-entry block in rabbit cells that results in aberrant trafficking of HIV-1.
Article in Traffic (Copenhagen, Denmark), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- The wide utility of rabbits as models of human diseases.Experimental & molecular medicine · 2018Review
- Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation.PLoS pathogens · 2017Article
- Apparent effect of rabbit endogenous lentivirus type K acquisition on retrovirus restriction by lagomorph Trim5αs.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.PLoS pathogens · 2011Article
- Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein.The Journal of biological chemistry · 2010Article
- High natural permissivity of primary rabbit cells for HIV-1, with a virion infectivity defect in macrophages as the final replication barrier.Journal of virology · 2010Article
- Transgenic rabbit production with simian immunodeficiency virus-derived lentiviral vector.Transgenic research · 2010Article
- Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides.Chemical biology & drug design · 2010Article
- HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome.Retrovirology · 2009Article
- An active TRIM5 protein in rabbits indicates a common antiviral ancestor for mammalian TRIM5 proteins.Journal of virology · 2007Article
- Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression.Retrovirology · 2007Article
- Multiple restrictions of human immunodeficiency virus type 1 in feline cells.Journal of virology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Rabbit cells are poorly permissive to HIV-1 infection, but little is known about the nature of this block. Here, we show that the block to infection is mainly at the level of reverse transcription (RT), is independent of the cell receptor used by the virus for entry, cannot be effectively saturated with high doses of virus or virus-like particles, and has a recessive phenotype in human-rabbit heterokaryons. RT complexes (RTCs) extracted from human and rabbit cells have different densities but are both competent for RT in an in vitro endogenous assay. Cell fractionation showed that HIV-1 is trafficked in a different way in human and rabbit cells and that correct intracellular trafficking is linked to efficient RT and high infectivity in vivo. Viral DNA accumulated in rabbit cell nuclei only at a later stage and failed to associate with chromatin, suggesting a further block prior to integration. Our data point to the existence of cellular factors regulating the early stages of intracytoplasmic and possibly intranuclear HIV-1 trafficking.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.