ReviewMolecular psychiatry2006
Approaching the shared biology of obesity and depression: the stress axis as the locus of gene-environment interactions.
Review in Molecular psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 4 syntheses or guidelines pooled it, 259 citations in OpenAlex.
- Obesity and its association with mental health among Mexican children and adolescents: systematic review.Nutrition reviews · 2023Pooled it
- Pooled it
- Association of metabolically healthy obesity with depressive symptoms: pooled analysis of eight studies.Molecular psychiatry · 2014Pooled it
- Global meta-analysis of the C-11377G alteration in the ADIPOQ gene indicates the presence of population-specific effects: challenge for global health initiatives.The pharmacogenomics journal · 2009Pooled it
- Trial
- Trial
- In Vitro Investigation of the Toxicity Mechanisms of Antidepressant Drugs on Adipose Tissue in 3T3-L1 Cells.Journal of applied toxicology : JAT · 2026Article
- Sex-specific circadian and behavioral phenotypes in aged growth hormone receptor knockout mice.GeroScience · 2026Article
- Interaction of serum resistin and smoking behavior in predicting depression risk: a sex-sensitive analysis.BMC psychiatry · 2026Article
- Association Between Body Mass Index and Depression/Anxiety in an East Asian Population: A Mendelian Randomization Study.The Kaohsiung journal of medical sciences · 2026Article
- Amino Acids as Metabokines in Hypercatabolic States: Rethinking Nutritional Protein-Based Strategies Beyond Caloric Support.Nutrients · 2026Review
- Diet Quality, Nutrition Knowledge, and Social Media-Driven Supplement Use Among Polish Adolescents and Young Adults: A Cross-Sectional Study.Nutrients · 2026Article
- Obesity and Depression.Advances in experimental medicine and biology · 2026Review
- Abdominal Obesity Indices as Predictors of Psychiatric Morbidity in a Large-Scale Taiwanese Cohort.Nutrients · 2025Article
- Parallel Pathways, Divergent Outcomes: Adipose Tissue-Neural Crosstalk in Depression and Obesity.Journal of clinical medicine · 2025Review
- Association between body roundness index and trajectories of depressive symptoms among Chinese middle-aged and older adults: a nationwide cohort study from CHARLS.BMC psychology · 2025Article
- The emergence of chronic diseases of adulthood and middle age in the young: the COIDS (chronic inflammation, obesity, insulin resistance/type 2 diabetes, and depressive syndromes) noxious quartet of pro-inflammatory stress outcomes.Molecular psychiatry · 2025Review
- Association between Life's Essential 8 and depression: a population-based study.Archives of medical science : AMS · 2025Article
- Electroceuticals: Unlocking the promise of therapies.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Review
- Early-life obesogenic environment integrates immunometabolic and epigenetic signatures governing neuroinflammation.Brain, behavior, & immunity - health · 2024Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Obesity and depression are serious public health problems and also constitute cardiovascular disease risk factors. Research organizations have called for efforts to explore the interrelationship between obesity and depression. A useful starting point is the fact that in both disorders there is dysregulation of stress systems. We review molecular and clinical evidence indicating that the mediators of the stress response are a key locus for gene-environment interactions in the shared biology of depression and obesity. Scientific milestones include translational paradigms such as mice knockouts, imaging and pharmacogenomic approaches that can identify new therapeutic strategies for those burdened by these two afflictions of contemporary civilization. Perspectives for the future are promising. Our ability to dissect the underpinnings of common and complex diseases with shared substrates will be greatly enhanced by the Genes and Environment Initiative, the emerging Large Scale Studies of Genes and Environment in Common Disease, and the UK Biobank Project.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.