ArticleMolecular and cellular biology2006
Genetic analysis of myc and telomerase interactions in vivo.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- The SIRT1-c-Myc axis in regulation of stem cells.Frontiers in cell and developmental biology · 2023Review
- The Connection Between Cell Fate and Telomere.Advances in experimental medicine and biology · 2021Review
- Biogerontology: research status, challenges and opportunities.Acta bio-medica : Atenei Parmensis · 2018Review
- Article
- Synthesis and antitumor mechanism of a new iron(iii) complex with 5,7-dichloro-2-methyl-8-quinolinol as ligands.MedChemComm · 2017Article
- Preparation of 6/8/11-Amino/Chloro-Oxoisoaporphine and Group-10 Metal Complexes and Evaluation of Their in Vitro and in Vivo Antitumor Activity.Scientific reports · 2016Article
- Saccharomyces cerevisiae as a model for the study of extranuclear functions of mammalian telomerase.Current genetics · 2015Article
- Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity.The Journal of clinical investigation · 2015Article
- SIRT1 is necessary for proficient telomere elongation and genomic stability of induced pluripotent stem cells.Stem cell reports · 2014Article
- c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telomeric and nontelomeric regions of DNA.The Journal of biological chemistry · 2014Article
- Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer.EMBO molecular medicine · 2012Article
- Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells.Cell research · 2012Article
- PinX1 inhibits telomerase activity in gastric cancer cells through Mad1/c-Myc pathway.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2010Article
- Progress & prospects: gene therapy in aging.Gene therapy · 2009Review
- MYC in mammalian epidermis: how can an oncogene stimulate differentiation?Nature reviews. Cancer · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myc is a transcription factor with pleiotropic effects on tumorigenesis which are likely to be mediated by its target genes. A known Myc transcriptional target is the catalytic subunit of telomerase, Tert. However, the contribution of Tert activation to Myc-induced tumorigenesis in vivo remains unknown. In this study, we addressed the role of telomerase in Myc-induced skin papillomatosis by using compound mice with a switchable Myc gene, Inv-MycERTAM mice, in combination with either telomerase deficiency (Terc-/-) or telomerase overexpression (K5-mTert) in the skin. We first demonstrated that Myc activates telomerase in the skin. With Inv-MycERTAM x Terc-/- mice, we further showed that this telomerase activation is partially required to elicit a full hyperplastic Myc-induced response. The presence of critically short telomeres in late-generation Inv-MycERTAM x Terc-/- mice further reduced the skin lesion induced by Myc. On the other hand, telomerase overexpression in the skin of K5-mTert mice augments Myc-induced hyperplasia in the absence of changes in telomere length, suggesting a direct role of telomerase in the Myc protumorigenic response. Taken together, these results highlight telomerase as a mediator of Myc-induced papillomatosis and suggest telomerase as a putative therapeutic target for Myc-dependent lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.