ArticleMolecular and cellular biology2006
Differential gene regulation by selective association of transcriptional coactivators and bZIP DNA-binding domains.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Article
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- HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells.Molecular and cellular biology · 2020Article
- Article
- Insights from the crystal structure of the chicken CREB3 bZIP suggest that members of the CREB3 subfamily transcription factors may be activated in response to oxidative stress.Protein science : a publication of the Protein Society · 2019Article
- Unraveling the induction of phytoene synthase 2 expression by salt stress and abscisic acid in Daucus carota.Journal of experimental botany · 2018Article
- Involvement of the Transcriptional Coactivator ThMBF1 in the Biocontrol Activity ofFrontiers in microbiology · 2017Article
- Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1.Oncotarget · 2016Article
- MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress.Epigenetics · 2014Article
- bZIPs and WRKYs: two large transcription factor families executing two different functional strategies.Frontiers in plant science · 2014Review
- Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The histone acetyltransferases CBP and Chameau integrate developmental and DNA replication programs in Drosophila ovarian follicle cells.Development (Cambridge, England) · 2012Article
- The MYST-containing protein Chameau is required for proper sensory organ specification during Drosophila thorax morphogenesis.PloS one · 2012Article
- JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.Molecular cell · 2011Article
- MYST-family histone acetyltransferases: beyond chromatin.Cellular and molecular life sciences : CMLS · 2011Review
- Functional analysis of archaeal MBF1 by complementation studies in yeast.Biology direct · 2011Article
- SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages.The Journal of biological chemistry · 2010Article
- HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.Molecular cell · 2010Article
- A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl-terminal extension of the DNA binding domain.The Journal of biological chemistry · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
bZIP DNA-binding domains are targets for viral and cellular proteins that function as transcriptional coactivators. Here, we show that MBF1 and the related Chameau and HBO1 histone acetylases interact with distinct subgroups of bZIP proteins, whereas pX does not discriminate. Selectivity of Chameau and MBF1 for bZIP proteins is mediated by residues in the basic region that lie on the opposite surface from residues that contact DNA. Chameau functions as a specific coactivator for the AP-1 class of bZIP proteins via two arginine residues. A conserved glutamic acid/glutamine in the linker region underlies MBF1 specificity for a subgroup of bZIP factors. Chameau and MBF1 cannot synergistically coactivate transcription due to competitive interactions with the basic region, but either protein can synergistically coactivate with pX. Analysis of Jun derivatives that selectively interact with these coactivators reveals that MBF1 is crucial for the response to oxidative stress, whereas Chameau is important for the response to chemical and osmotic stress. Thus, the bZIP domain mediates selective interactions with coactivators and hence differential regulation of gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.