ArticleProceedings of the National Academy of Sciences of the United States of America2006
Monitoring the T cell response to genital tract infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 67 citations in OpenAlex.
- Article
- Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways.bioRxiv : the preprint server for biology · 2025Article
- Secreted ISG15 induced by Chlamydia trachomatis infection exerts immunomodulatory effects on IFN-γ defense and inflammation.PLoS pathogens · 2025Article
- Article
- Cytotoxic CD4+ T Cells Are Induced during Infection with Chlamydia trachomatis.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Immunohistochemical characterization of the immune cell response during chlamydial infection in the male and female koala (Veterinary pathology · 2024Article
- The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protectingeLife · 2024Article
- Protective anti-chlamydial vaccine regimen-induced CD4+ T cell response mediates early inhibition of pathogenic CD8+ T cell response following genital challenge.Pathogens and disease · 2024Article
- Article
- Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery Systems.Vaccines · 2021Review
- Immunopathogenesis of genital Chlamydia infection: insights from mouse models.Pathogens and disease · 2021Review
- T cell responses to Chlamydia.Pathogens and disease · 2021Review
- Modulation of Immune Response toFrontiers in cellular and infection microbiology · 2021Article
- Mucosal Vaccination with UV-InactivatedVaccines · 2020Article
- Gamma Interferon Is Required formBio · 2020Article
- Antigen-specific memory and naïve CD4+ T cells following secondary Chlamydia trachomatis infection.PloS one · 2020Article
- Early Colonization of the Upper Genital Tract by Chlamydia muridarum Is Associated with Enhanced Inflammation Later in Infection.Infection and immunity · 2019Article
- A Chlamydia trachomatis Strain Expressing Ovalbumin Stimulates an Antigen-Specific CD4Infection and immunity · 2019Article
- Diversity in the T cell response to Chlamydia-sum are better than one.Immunology letters · 2018Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To date, it has not been possible to study antigen-specific T cell responses during primary infection of the genital tract. The low frequency of pathogen-specific T cells in a naïve mouse makes it difficult to monitor the initial events after antigen encounter. We developed a system to examine the response of pathogen-specific T cells in the genital mucosa after intrauterine infection. We identified the protective CD4(+) T cell antigen Cta1 from Chlamydia trachomatis and generated T cell receptor (TCR) transgenic (tg) mice with specificity for this protein. By transferring TCR tg T cells into naïve animals, we determined that Chlamydia-specific T cells were activated and proliferated in the lymph nodes draining the genital tract after primary intrauterine infection. Activated T cells migrated into the genital mucosa and secreted IFN-gamma. The development of Chlamydia-specific TCR tg mice provides an approach for dissecting how pathogen-specific T cells function in the genital tract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.