ArticleThe Journal of physiology1991
The peptide VIP is a neurotransmitter in rat adrenal medulla: physiological role in controlling catecholamine secretion.
Article in The Journal of physiology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 58 citations in OpenAlex.
- Modulation of spontaneous intracellular Ca²⁺ fluctuations and spontaneous cholinergic transmission in rat chromaffin cells in situ by endogenous GABA acting on GABAA receptors.Pflugers Archiv : European journal of physiology · 2016Article
- Catecholamine biosynthesis and secretion: physiological and pharmacological effects of secretin.Cell and tissue research · 2011Article
- Reprint of: Catestatin: a multifunctional peptide from chromogranin A.Regulatory peptides · 2010Article
- Catestatin: a multifunctional peptide from chromogranin A.Regulatory peptides · 2010Review
- Revisiting the stimulus-secretion coupling in the adrenal medulla: role of gap junction-mediated intercellular communication.Molecular neurobiology · 2009Review
- Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Role of neurotransmitters and neuropeptides in the regulation of the adrenal cortex.Reviews in endocrine & metabolic disorders · 2001Review
- Immunohistochemical localization of bioactive peptides and amines associated with the chromaffin tissue of five species of fish.Cell and tissue research · 1995Article
- Muscarinic involvement in vascular and adrenal medullary responses to splanchnic nerve stimulation in conscious calves.Experientia · 1994Article
- Differential secretion of catecholamines in response to peptidergic and cholinergic transmitters in rat adrenals.The Journal of physiology · 1994Article
- Regional haemodynamic responses to pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide in conscious rats.British journal of pharmacology · 1994Article
- Adrenal cortical and medullary responses to acetylcholine and vasoactive intestinal peptide in conscious calves.The Journal of physiology · 1993Article
- Non-cholinergic nervous control of catecholamine secretion from perfused bovine adrenal glands.The Journal of physiology · 1993Article
- Multiple signaling pathways in bovine chromaffin cells regulate tyrosine hydroxylase phosphorylation at Ser19, Ser31, and Ser40.Neurochemical research · 1993Article
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5 authors at 1 institution in 1 country.
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Abstract
1. The perfused adrenal gland of the rat was used to establish the identity of a non-cholinergic substance involved in splanchnic nerve-mediated secretion of catecholamines. 2. The perfused adrenal medulla was rich in vasoactive intestinal polypeptide (VIP) content (28 pmol g-1 of wet tissue). VIP-immunoreactive nerve fibres were present in the adrenal medulla and the adrenal cortex. 3. Field stimulation (10 Hz for 15 min plus 1 Hz for 15 min) caused a large increase in the output of VIP in the perfusate over the spontaneous release of VIP. Secretion of catecholamines was also greatly elevated by field stimulation. Field stimulation-evoked output of VIP and catecholamines was abolished after chronic denervation of the adrenal glands. 4. Infusion of acetylcholine (ACh) did not increase the output of VIP but caused a robust secretion of catecholamines. 5. The VIP output declined when the stimulation frequency was increased (8.6 x 10(-3) fmol pulse-1 at 1 Hz and 4.0 x 10(-3) fmol pulse-1 at 10 Hz). 6. In contrast, the output of 3H-acetylcholine (3H-ACh, expressed as a fraction of tissue 3H-ACh content) increased from 7.0 x 10(-2) pulse-1 at 1 Hz to 16.3 x 10(-2) pulse-1 at 10 Hz. 7. Secretion of catecholamines evoked by low-frequency stimulation (1 Hz) was reduced by 40% in the presence of cholinergic receptor antagonists (atropine plus hexamethonium). Inclusion of a VIP receptor antagonist ([Ac-Tyr1, D-Phe2]-GRF 1-29 amide) caused about 75% inhibition. 8. The VIP receptor antagonist inhibited VIP-evoked secretion of catecholamines without affecting ACh-evoked secretion. 9. In conclusion, VIP satisfies all the essential criteria to assume the role of a neurotransmitter in the rat adrenal medulla. The contribution of VIP to the secretion of adrenal medullary hormones is more prominent at low rates of neuronal activity whereas ACh is the major contributor at higher activity.
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