ArticleThe Journal of cell biology2006
mBet3p is required for homotypic COPII vesicle tethering in mammalian cells.
Article in The Journal of cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Phosphatidylinositol-4-phosphate signaling regulates dense granule biogenesis and maturation in Toxoplasma gondii.PLoS pathogens · 2026Article
- Mea6/cTAGE5 cooperates with TRAPPC12 to regulate PTN secretion and white matter development.iScience · 2024Article
- Endoplasmic reticulum-to-Golgi trafficking of procollagen III via conventional vesicular and tubular carriers.Molecular biology of the cell · 2022Article
- Emerging role of NIK/IKK2-binding protein (NIBP)/trafficking protein particle complex 9 (TRAPPC9) in nervous system diseases.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Visualization of Procollagen IV Reveals ER-to-Golgi Transport by ERGIC-independent Carriers.Cell structure and function · 2020Article
- The TRAPP complex mediates secretion arrest induced by stress granule assembly.The EMBO journal · 2019Article
- Proximity-dependent proteomics of the Chlamydia trachomatis inclusion membrane reveals functional interactions with endoplasmic reticulum exit sites.PLoS pathogens · 2019Article
- The TRAPPIII complex activates the GTPase Ypt1 (Rab1) in the secretory pathway.The Journal of cell biology · 2018Article
- TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Mammalian TRAPPIII Complex positively modulates the recruitment of Sec13/31 onto COPII vesicles.Scientific reports · 2017Article
- Host Cellular Protein TRAPPC6AΔ Interacts with Influenza A Virus M2 Protein and Regulates Viral Propagation by Modulating M2 Trafficking.Journal of virology · 2017Article
- Coat/Tether Interactions-Exception or Rule?Frontiers in cell and developmental biology · 2016Review
- Article
- Spatial and Functional Aspects of ER-Golgi Rabs and Tethers.Frontiers in cell and developmental biology · 2016Article
- TFG clusters COPII-coated transport carriers and promotes early secretory pathway organization.The EMBO journal · 2015Article
- Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium.The Journal of biological chemistry · 2014Article
- Complexes of Usher proteins preassemble at the endoplasmic reticulum and are required for trafficking and ER homeostasis.Disease models & mechanisms · 2014Article
- The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi.Cold Spring Harbor perspectives in biology · 2013Review
- A trapper keeper for TRAPP, its structures and functions.Cellular and molecular life sciences : CMLS · 2012Review
- Bcl-2 family member Bcl-G is not a proapoptotic protein.Cell death & disease · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
TRAPPI is a large complex that mediates the tethering of COPII vesicles to the Golgi (heterotypic tethering) in the yeast Saccharomyces cerevisiae. In mammalian cells, COPII vesicles derived from the transitional endoplasmic reticulum (tER) do not tether directly to the Golgi, instead, they appear to tether to each other (homotypic tethering) to form vesicular tubular clusters (VTCs). We show that mammalian Bet3p (mBet3p), which is the most highly conserved TRAPP subunit, resides on the tER and adjacent VTCs. The inactivation of mBet3p results in the accumulation of cargo in membranes that colocalize with the COPII coat. Furthermore, using an assay that reconstitutes VTC biogenesis in vitro, we demonstrate that mBet3p is required for the tethering and fusion of COPII vesicles to each other. Consistent with the proposal that mBet3p is required for VTC biogenesis, we find that ERGIC-53 (VTC marker) and Golgi architecture are disrupted in siRNA-treated mBet3p-depleted cells. These findings imply that the TRAPPI complex is essential for VTC biogenesis.
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Registered trials
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