ArticleThe Journal of experimental medicine2006
Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help.
Article in The Journal of experimental medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The trial behind it
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Lifelong Evolution of Autoreactive Plasma Cell Numbers, Affinity, and Anatomic Location in Arthritic K/BxN Mice.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance.Cellular & molecular immunology · 2024Article
- Homeostasis and regulation of autoreactive B cells.Cellular & molecular immunology · 2020Review
- B-cell tolerance and autoimmunity.F1000Research · 2017Review
- IDO2 Modulates T Cell-Dependent Autoimmune Responses through a B Cell-Intrinsic Mechanism.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Targeting of Ly9 (CD229) Disrupts Marginal Zone and B1 B Cell Homeostasis and Antibody Responses.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Requirement for Transcription Factor Ets1 in B Cell Tolerance to Self-Antigens.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- B Cell-Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell-Dependent Immune Response In Vivo.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Addition of an indoleamine 2,3,-dioxygenase inhibitor to B cell-depletion therapy blocks autoreactive B cell activation and recurrence of arthritis in K/BxN mice.Arthritis and rheumatism · 2012Article
- Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis.Cellular & molecular immunology · 2011Article
- Autoreactive marginal zone B cells enter the follicles and interact with CD4+ T cells in lupus-prone mice.BMC immunology · 2011Article
- Characterization of the KRN cell transfer model of rheumatoid arthritis (KRN-CTM), a chronic yet synchronized version of the K/BxN mouse.The American journal of pathology · 2010Article
- BAFF overexpression promotes anti-dsDNA B-cell maturation and antibody secretion.Cellular immunology · 2010Article
- Generation of B cell memory to the bacterial polysaccharide alpha-1,3 dextran.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Class-switched B cells display response to therapeutic B-cell depletion in rheumatoid arthritis.Arthritis research & therapy · 2009Article
- DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes.Nature · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In K/BxN mice, arthritis is induced by autoantibodies against glucose-6-phosphate-isomerase (GPI). To investigate B cell tolerance to GPI in nonautoimmune mice, we increased the GPI-reactive B cell frequency using a low affinity anti-GPI H chain transgene. Surprisingly, anti-GPI B cells were not tolerant to this ubiquitously expressed and circulating autoantigen. Instead, they were found in two functionally distinct compartments: an activated population in the splenic marginal zone (MZ) and an antigenically ignorant one in the recirculating follicular/lymph node (LN) pool. This difference in activation was due to increased autoantigen availability in the MZ. Importantly, the LN anti-GPI B cells remained functionally competent and could be induced to secrete autoantibodies in response to cognate T cell help in vitro and in vivo. Therefore, our study of low affinity autoreactive B cells reveals two distinct but potentially concurrent mechanisms for their activation, of which one is T cell dependent and the other is T cell independent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.