ArticleClinical and experimental immunology2006
Mannose-binding lectin does not act as an acute-phase reactant in adults with community-acquired pneumococcal pneumonia.
Article in Clinical and experimental immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Host genetic variability and pneumococcal disease: a systematic review and meta-analysis.BMC medical genomics · 2019Pooled it
- The ambiguous role of mannose-binding lectin (MBL) in human immunity.Open medicine (Warsaw, Poland) · 2021Review
- Mannose-Binding Lectin is Associated with Thrombosis and Coagulopathy in Critically Ill COVID-19 Patients.Thrombosis and haemostasis · 2020Article
- Targeting the complement system in bacterial meningitis.Brain : a journal of neurology · 2019Review
- Observational
- Low Levels of Immunoglobulins and Mannose-Binding Lectin Are Not Associated With Etiology, Severity, or Outcome in Community-Acquired Pneumonia.Open forum infectious diseases · 2018Article
- Mannose-binding lectin and l-ficolin polymorphisms in patients with community-acquired pneumonia caused by intracellular pathogens.Immunology · 2017Article
- Circulating mannan-binding lectin, M-, L-, H-ficolin and collectin-liver-1 levels in patients with acute liver failure.Liver international : official journal of the International Association for the Study of the Liver · 2015Article
- Article
- Alcohol abuse and Streptococcus pneumoniae infections: consideration of virulence factors and impaired immune responses.Alcohol (Fayetteville, N.Y.) · 2011Review
- Mannose-binding lectin deficiency and respiratory tract infection.Journal of innate immunity · 2010Review
- Acute-phase responsiveness of mannose-binding lectin in community-acquired pneumonia is highly dependent upon MBL2 genotypes.Clinical and experimental immunology · 2009Article
- Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2008Article
- Low mannose-binding lectin complement activation function is associated with predisposition to Legionnaires' disease.Clinical and experimental immunology · 2007Article
- AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid.Respiratory research · 2007Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this work was to study the role of mannose-binding lectin (MBL) and C-reactive protein (CRP) in pneumococcal pneumonia, to determine whether MBL acts as an acute-phase reactant and whether the severity of the disease correlates with MBL levels. The study comprised 100 patients with pneumococcal pneumonia. The pneumonia severity score was calculated and graded into a risk class of mortality (Fine scale). The MBL genotypes and the levels of MBL and CRP at the acute and recovery phases were determined. Fifty patients with the wild-type MBL genotype showed higher MBL levels in each phase (P < 0.001) and an increased risk to developing bacteraemia, odds ratio (OR) 2.74, 95% confidence interval (CI) 1.01-7.52) (P = 0.02), but this did not correlate with the pneumonia severity class. CRP levels in the acute phase, 79.53 mg/l [standard deviation (s.d.) 106.93], were higher in the subjects with positive blood cultures (P = 0.003), and remained higher [20.12 mg/l (s.d. 31.90)] in the group of patients with an underlying disease (P = 0.01). No correlation was observed between the levels of MBL and CRP in each phase, or with the pneumonia severity score. We cannot conclude that MBL acts uniformly as an acute-phase reactant in pneumococcal pneumonia. MBL levels do not correlate well with the severity of the pneumonia. The risk of developing bacteraemia could be enhanced in individuals with the wild-type MBL genotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.