ArticleClinical and experimental immunology2006
Toll-like receptor (TLR) 4 polymorphism Asp299Gly is not associated with disease course in Dutch sarcoidosis patients.
Article in Clinical and experimental immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Sarcoidosis vs. Sarcoid-like reactions: The Two Sides of the same Coin?Wiener medizinische Wochenschrift (1946) · 2014Review
- Disordered Toll-like receptor 2 responses in the pathogenesis of pulmonary sarcoidosis.Clinical and experimental immunology · 2013Article
- Polymorphisms and haplotypes in MyD88 are associated with the development of sarcoidosis: a candidate-gene association study.Molecular biology reports · 2013Article
- Toll like receptors in diseases of the lung.International immunopharmacology · 2011Review
- Toll-like receptor 2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population.Molecular vision · 2011Article
- Toll-like receptor (TLR)-9 genetics and function in sarcoidosis.Clinical and experimental immunology · 2010Article
- Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan.Molecular vision · 2009Article
- Association of the TLR4 Asp299Gly polymorphism with lung function in relation to body mass index.BMC pulmonary medicine · 2009Article
- Giant cell formation in sarcoidosis: cell fusion or proliferation with non-division?Clinical and experimental immunology · 2009Article
- Higher monocyte expression of TLR2 and TLR4, and enhanced pro-inflammatory synergy of TLR2 with NOD2 stimulation in sarcoidosis.Journal of clinical immunology · 2009Article
- Study of Toll-like receptor gene loci in sarcoidosis.Clinical and experimental immunology · 2008Article
- Linkage between Toll-like receptor (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis.Clinical and experimental immunology · 2007Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aetiology of sarcoidosis, a systemic disorder characterized by the formation of non-caseating granulomas in variable organs, remains enigmatic. Clarification is hampered by heterogeneity in disease phenotypes and course, due partly to the influence of a variety of genetic and environmental factors. Multiple studies have pointed towards bacteria as possible causative agents. Toll-like receptors (TLR) are innate immunity receptors important in the immune response against pathogens. TLR-4, together with CD14 and MD-2, is an essential receptor for the recognition of lipopolysaccharide (LPS), unique to the cell wall of Gram-negative bacteria. Recently, an association between TLR-4 polymorphism Asp299Gly, leading to a change in the extracellular domain of the receptor and possible hyporesponsiveness to LPS, and a chronic course of sarcoidosis was found in German patients. In the present study this polymorphism was genotyped in 156 Dutch sarcoidosis patients and 200 healthy Dutch controls using dual-labelled fluorescent oligonucleotides. No differences were found in allelic distributions between patients and controls (P = 0.79) or within the different clinical entities of the sarcoidosis group (P = 0.44). Importantly, there were no differences between the Dutch and German sarcoidosis patients (P = 0.62). However, the allelic distribution of the Asp299Gly polymorphism differed significantly between both control groups (P = 0.04). This study highlights the importance of testing a reported gene association in a distinct population when performing genetic association studies.
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