Trial reportSao Paulo medical journal = Revista paulista de medicina2006
Effects of single dose of dexamethasone on patients with systemic inflammatory response.
Trial report in Sao Paulo medical journal = Revista paulista de medicina, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03876041 (Evaluation of Corticosteroid as Modulators of Humeral and Cellular Immune Response in Open Heart Surgery in Egyptian Population), which is not on this map. Cited by 14 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Corticosteroid as Modulators of Humeral and Cellular Immune Response in Open Heart Surgery in Egyptian Population
Who cites it
14 citing papers in PubMed, 5 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Corticosteroids for treating sepsis in children and adults.The Cochrane database of systematic reviews · 2025Pooled it
- Corticosteroids for Treating Sepsis in Adult Patients: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2021Pooled it
- Corticosteroids for treating sepsis in children and adults.The Cochrane database of systematic reviews · 2019Pooled it
- Corticosteroids for treating sepsis.The Cochrane database of systematic reviews · 2015Pooled it
- Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis.Intensive care medicine · 2015Pooled it
- Early dexamethasone treatment for septic shock patients: a prospective randomized clinical trial.Sao Paulo medical journal = Revista paulista de medicina · 2007Trial
- Risk Factors for a Systemic Inflammatory Response After Major Oral Cancer Surgery with Microvascular Free Flap Reconstruction: An Exploratory Retrospective Analysis.Journal of inflammation research · 2026Article
- The Impact of Intraoperative Dexamethasone and Mannitol on Postoperative Inflammatory Response in Totally Tubeless Percutaneous Nephrolithotomy: A Prospective, Double-Blind, Controlled Clinical Trial.Advances in urology · 2026Article
- First hematological and biochemical findings in a rehabilitated giant pangolin (Frontiers in veterinary science · 2026Article
- Article
- The retrospective study of perioperative application of dexamethasone and furosemide for postoperative anti-inflammation in patients undergoing percutaneous nephrolithotomy.International urology and nephrology · 2021Article
- Inhibition of endogenous glucocorticoid synthesis aggravates lung injury triggered by septic shock in rats.International journal of experimental pathology · 2015Article
- Low-dose steroids for septic shock and severe sepsis: the use of Bayesian statistics to resolve clinical trial controversies.Intensive care medicine · 2011Review
- C-reactive protein is not a useful indicator for infection in surgical intensive care units.Sao Paulo medical journal = Revista paulista de medicina · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CONTEXT AND
objectiveSystemic inflammatory response syndrome (SIRS) is a very common condition among critically ill patients. SIRS, sepsis, septic shock and multiple organ dysfunction syndrome (MODS) can lead to death. Our aim was to investigate the efficacy of a single dose of dexamethasone for blocking the progression of systemic inflammatory response syndrome. DESIGN AND
settingProspective, randomized, double-blind, single-center study in a postoperative intensive care unit (Surgical Support Unit) at Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo.
methodsThe study involved 29 patients with SIRS. All eligible patients were prospectively randomized to receive either a single dose of 0.2 mg/kg of dexamethasone or placebo, after SIRS was diagnosed. The patients were monitored over a seven-day period using Sequential Organ Failure Assessment score (SOFA).
resultsThe respiratory system showed an improvement on the first day after dexamethasone was administered, demonstrated by the improved PaO2/FiO2 ratio (p < 0.05). The cardiovascular system of patients requiring vasopressor therapy also improved over the first two days, with a better evolution in the dexamethasone group (p < 0.05). Non-surviving patients presented higher lactate assays than did survivors (p < 0.05) during this period.
conclusionsDexamethasone enhanced the effects of vasopressor drugs and evaluation of the respiratory system showed improvements (better PaO2/FiO2 ratio), one day after its administration. Despite these improvements, the single dose of dexamethasone did not block the evolution of SIRS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.