ReviewSexually transmitted infections2006
The case for further treatment studies of uncomplicated genital Chlamydia trachomatis infection.
Review in Sexually transmitted infections, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Interventions for treating genital Chlamydia trachomatis infection in pregnancy.The Cochrane database of systematic reviews · 2017Pooled it
- Chlamydia (uncomplicated, genital).BMJ clinical evidence · 2015Pooled it
- On the pathway to better birth outcomes? A systematic review of azithromycin and curable sexually transmitted infections.Expert review of anti-infective therapy · 2013Pooled it
- Chlamydia (uncomplicated, genital).BMJ clinical evidence · 2010Pooled it
- Chlamydia (uncomplicated, genital).BMJ clinical evidence · 2008Pooled it
- Trial
- A cohort study of Chlamydia trachomatis treatment failure in women: a study protocol.BMC infectious diseases · 2013Trial
- Chlamydia trachomatis, Mycoplasma genitalium, and Trichomonas vaginalis infections in men with nongonococcal urethritis: predictors and persistence after therapy.The Journal of infectious diseases · 2012Trial
- Phenotypic and Genotypic Antimicrobial Susceptibility Testing ofAntibiotics (Basel, Switzerland) · 2023Article
- Repeat infections with chlamydia in women may be more transcriptionally active with lower responses from some immune genes.Frontiers in public health · 2022Article
- Treatment Effectiveness of Azithromycin and Doxycycline in Uncomplicated Rectal and Vaginal Chlamydia trachomatis Infections in Women: A Multicenter Observational Study (FemCure).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Observational
- Elaborations on Corallopyronin A as a Novel Treatment Strategy Against Genital Chlamydial Infections.Frontiers in microbiology · 2019Article
- Current Research of Chlamydial Infection Diseases in China.Chinese medical journal · 2018Article
- Draft Genome Sequence of Chlamydia trachomatis Strain 54, Isolated from the Urogenital Tract of a Male in Japan.Genome announcements · 2015Article
- Differences in 23S ribosomal RNA mutations between wild-type and mutant macrolide-resistantExperimental and therapeutic medicine · 2015Article
- Treatment challenges for urogenital and anorectal Chlamydia trachomatis.BMC infectious diseases · 2015Review
- Induction of the Chlamydia muridarum stress/persistence response increases azithromycin treatment failure in a murine model of infection.Antimicrobial agents and chemotherapy · 2014Article
- Commonly prescribed β-lactam antibiotics induce C. trachomatis persistence/stress in culture at physiologically relevant concentrations.Frontiers in cellular and infection microbiology · 2014Article
- Differential susceptibilities to azithromycin treatment of chlamydial infection in the gastrointestinal tract and cervix.Antimicrobial agents and chemotherapy · 2013Article
- Genital Chlamydia trachomatis: an update.The Indian journal of medical research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Azithromycin 1 g immediately and doxycycline 100 mg twice daily have good antimicrobial activity against Chlamydia trachomatis and treatment studies have demonstrated a >95% microbiological cure at 2-5 weeks, with antimicrobial resistance being rarely reported. Recently an 8% (95%, CI 5% to 11%) failure rate was observed in 289 women, but not in men, who had been sexually inactive after treatment. At high multiplicities of infection (load) in vitro persistence can often be demonstrated to antimicrobials-heterotypic resistance. The subsequently recovered isolates do not possess antimicrobial resistance at low loads. It is known that genital chlamydia load varies in vivo and is probably greater in women than men. In mass treatment trials of trachoma, treatment failure is associated with high chlamydia loads. It is therefore possible that women with high chlamydia loads may be at increased risk of treatment failure. Given the imminent role out of the National Chlamydia Screening Programme and the consequences of persistent chlamydial infection in women this hypothesis urgently merits further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.