ArticleProceedings of the National Academy of Sciences of the United States of America2006
Transcriptional regulation by Modulo integrates meiosis and spermatid differentiation in male germ line.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Article
- Derepression of Y-linked multicopy protamine-like genes interferes with sperm nuclear compaction inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The potential for a CRISPR gene drive to eradicate or suppress globally invasive social wasps.Scientific reports · 2020Article
- Evidence for a hierarchical transcriptional circuit in Drosophila male germline involving testis-specific TAF and two gene-specific transcription factors, Mod and Acj6.FEBS letters · 2018Article
- Distinctive pattern of expression of spermatogenic molecular markers in testes of azoospermic men with non-mosaic Klinefelter syndrome.Journal of assisted reproduction and genetics · 2016Article
- Nucleolar activity and CENP-C regulate CENP-A and CAL1 availability for centromere assembly in meiosis.Development (Cambridge, England) · 2016Article
- Relocation facilitates the acquisition of short cis-regulatory regions that drive the expression of retrogenes during spermatogenesis in Drosophila.Molecular biology and evolution · 2014Article
- A role for the CAL1-partner Modulo in centromere integrity and accurate chromosome segregation in Drosophila.PloS one · 2012Article
- Identification of nucleolin as a cellular receptor for human respiratory syncytial virus.Nature medicine · 2011Article
- A novel predicted bromodomain-related protein affects coordination between meiosis and spermiogenesis in Drosophila and is required for male meiotic cytokinesis.DNA and cell biology · 2010Article
- Identification of a novel nucleolin related protein (NRP) gene expressed during rat spermatogenesis.BMC molecular biology · 2009Article
- Up-regulation of the Ku heterodimer in Drosophila testicular cyst cells.FEBS letters · 2007Article
- Tombola, a tesmin/TSO1-family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with always early.Development (Cambridge, England) · 2007Article
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Authors and funding
3 authors at 1 institution in 2 countries.
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Abstract
Transcriptional activation in early spermatocytes involves hundreds of genes, many of which are required for meiosis and spermatid differentiation. A number of the meiotic-arrest genes have been identified as general regulators of transcription; however, the gene-specific transcription factors have remained elusive. To identify such factors, we purified the protein that specifically binds to the promoter of spermatid-differentiation gene Sdic and identified it as Modulo, the Drosophila homologue of nucleolin. Analysis of gene-expression patterns in the male sterile modulo mutant indicates that Modulo supports high expression of the meiotic-arrest genes and is essential for transcription of spermatid-differentiation genes. Expression of Modulo itself is under the control of meiotic-arrest genes and requires the DAZ/DAZL homologue Boule that is involved in the control of G(2)/M transition. Thus, regulatory interactions among Modulo, Boule, and the meiotic-arrest genes integrate meiosis and spermatid differentiation in the male germ line.
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