ArticleBiophysical journal2006
Deformations in actin comets from rocketing beads.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Reconstituted systems for studying the architecture and dynamics of actin networks.The Biochemical journal · 2025Review
- Programmable DNA-augmented hydrogels for controlled activation of human lymphocytes.Nanomedicine : nanotechnology, biology, and medicine · 2021Article
- Triggering signaling pathways using F-actin self-organization.Scientific reports · 2016Article
- How actin network dynamics control the onset of actin-based motility.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Actin filament attachments for sustained motility in vitro are maintained by filament bundling.PloS one · 2012Article
- A model actin comet tail disassembling by severing.Physical biology · 2011Article
- Force generation of curved actin gels characterized by combined AFM-epifluorescence measurements.Biophysical journal · 2010Article
- Cell biology: actin filaments up against a wall.Nature · 2010Article
- Effects of molecular-scale processes on observable growth properties of actin networks.Physical review. E, Statistical, nonlinear, and soft matter physics · 2010Article
- Force-velocity relation for actin-polymerization-driven motility from Brownian dynamics simulations.Biophysical journal · 2009Article
- In silico reconstitution of actin-based symmetry breaking and motility.PLoS biology · 2009Article
- Physical model of cellular symmetry breaking.Cold Spring Harbor perspectives in biology · 2009Review
- Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency.Molecular biology of the cell · 2009Article
- Models for actin polymerization motors.Journal of mathematical biology · 2009Review
- New proposed mechanism of actin-polymerization-driven motility.Biophysical journal · 2008Article
- Non-Gaussian curvature distribution of actin-propelled biomimetic colloid trajectories.European biophysics journal : EBJ · 2008Article
- Physical model of contractile ring initiation in dividing cells.Biophysical journal · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanical and dynamical properties of the actin network are essential for many cellular processes like motility or division, and there is a growing body of evidence that they are also important for adhesion and trafficking. The leading edge of migrating cells is pushed out by the polymerization of actin networks, a process orchestrated by cross-linkers and other actin-binding proteins. In vitro physical characterizations show that these same proteins control the elastic properties of actin gels. Here we use a biomimetic system of Listeria monocytogenes, beads coated with an activator of actin polymerization, to assess the role of various actin-binding proteins in propulsion. We find that the properties of actin-based movement are clearly affected by the presence of cross-linkers. By monitoring the evolution of marked parts of the comet, we provide direct experimental evidence that the actin gel continuously undergoes deformations during the growth of the comet. Depending on the protein composition in the motility medium, deformations arise from either gel elasticity or monomer diffusion through the actin comet. Our findings demonstrate that actin-based movement is governed by the mechanical properties of the actin network, which are fine-tuned by proteins involved in actin dynamics and assembly.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.