ArticleBiophysical journal2006
Phase separation in bilayer lipid membranes: effects on the inner leaf due to coupling to the outer leaf.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences.Cold Spring Harbor perspectives in biology · 2023Review
- Understanding the free-energy landscape of phase separation in lipid bilayers using molecular dynamics.Biophysical journal · 2023Article
- Understanding the Free Energy Landscape of Phase Separation in Lipid Bilayers using Molecular Dynamics.bioRxiv : the preprint server for biology · 2023Article
- Thy-1, a Pathfinder Protein for the Post-genomic Era.Frontiers in cell and developmental biology · 2018Review
- Alteration of interleaflet coupling due to compounds displaying rapid translocation in lipid membranes.Scientific reports · 2016Article
- Registered and antiregistered phase separation of mixed amphiphilic bilayers.Biophysical journal · 2015Article
- Lipid domains in HIV-1 assembly.Frontiers in microbiology · 2014Review
- Interleaflet coupling and domain registry in phase-separated lipid bilayers.Biophysical journal · 2011Article
- Critical dynamics of lateral and transversal phase separations in bilayer biomembranes and surfactants.The European physical journal. E, Soft matter · 2009Article
- Coupled diffusion of peripherally bound peptides along the outer and inner membrane leaflets.Biophysical journal · 2009Article
- An introduction to critical points for biophysicists; observations of compositional heterogeneity in lipid membranes.Biochimica et biophysica acta · 2009Review
- Interleaflet coupling mechanisms in bilayers of lipids and cholesterol.Biophysical journal · 2008Article
- Phase behavior of a model bilayer membrane with coupled leaves.Biophysical journal · 2008Article
- Tuning lipid mixtures to induce or suppress domain formation across leaflets of unsupported asymmetric bilayers.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Influence of monolayer-monolayer coupling on the phase behavior of a fluid lipid bilayer.Biophysical journal · 2007Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The combined effects of the tendency of cholesterol to order lipids in the liquid phase and the coupling between lipids in the two leaves of a bilayer are investigated theoretically utilizing a Landau free energy. We show that as a consequence of these combined effects, lateral phase separation in the outer leaf between cholesterol-rich and -poor liquids causes a similar, but weaker, phase separation in the inner leaf. Just as the areal density of lipids in the outer leaf increases in the cholesterol-rich regions, so the areal density of lipids also increases in the inner leaf. Thus, the areal density in the inner leaf varies spatially, reflecting spatial variations of the areal density in the outer leaf. This provides a mechanism for proteins attached to the inner leaf via a hydrocarbon tether to respond to variations in the composition of the outer leaf. We also note that the effect of coupling between the leaves should be observable in artificial bilayers.
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