ArticleThe American journal of pathology2006
MDM2: a novel mineralocorticoid-responsive gene involved in aldosterone-induced human vascular structural remodeling.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Loci influencing blood pressure identified using a cardiovascular gene-centric array.Human molecular genetics · 2013Pooled it
- Machine learning-derived prognostic signature integrating programmed cell death and mitochondrial function in renal clear cell carcinoma: identification of PIF1 as a novel target.Cancer immunology, immunotherapy : CII · 2025Article
- Renal Injuries in Primary Aldosteronism: Quantitative Histopathological Analysis of 19 Patients With Primary Adosteronism.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Considering the Role of Murine Double Minute 2 in the Cardiovascular System?Frontiers in cell and developmental biology · 2019Review
- The emerging role of aldosterone/mineralocorticoid receptors in the pathogenesis of erectile dysfunction.Endocrine · 2018Review
- Mineralocorticoid receptor antagonism reverses diabetes-related coronary vasodilator dysfunction: A unique vascular transcriptomic signature.Pharmacological research · 2018Article
- Mineralocorticoid receptor antagonism protects the aorta from vascular smooth muscle cell proliferation and collagen deposition in a rat model of adrenal aldosterone-producing adenoma.Journal of physiology and biochemistry · 2018Article
- 3β-Hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma.Molecular and cellular endocrinology · 2015Article
- Pathogenesis of pulmonary arterial hypertension: lessons from cancer.European respiratory review : an official journal of the European Respiratory Society · 2013Review
- Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension.Circulation · 2013Article
- Estrogen-related receptor α in normal adrenal cortex and adrenocortical tumors: involvement in development and oncogenesis.Molecular and cellular endocrinology · 2013Article
- Article
- Aldosterone: effects on the kidney and cardiovascular system.Nature reviews. Nephrology · 2010Review
- Vasohibin-1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast.Cancer science · 2010Article
- Is the mineralocorticoid receptor a potential target for stroke prevention?Clinical science (London, England : 1979) · 2008Review
- The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology.Nuclear receptor signaling · 2007Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aldosterone has been demonstrated to play an important role in the pathogenesis of various cardiovascular diseases. Vascular structural remodeling, including vascular smooth muscle cell (VSMC) proliferation, has been also reported in small resistance arteries of patients with primary aldosteronism. Therefore, in this study, we examined whether genes involved in the regulation of the cell cycle were induced by aldosterone alone in cultured human VSMCs and in human small resistance arteries. Results of these studies eventually demonstrated that MDM2, one of the genes involved in anti-apoptosis and cell growth, was markedly increased in mineralocorticoid receptor (MR)-positive VSMCs by aldosterone in all microarray, reverse transcriptase-polymerase chain reaction, immunoblotting, and immunofluorescence analyses. In addition, an analysis using small interfering RNA demonstrated that this gene product was involved in cell proliferation of VSMCs induced by aldosterone. Eplerenone, a specific MR antagonist, inhibited this gene induction by aldosterone in VSMCs. MDM2 protein was also more abundant in VSMCs of small resistance arteries in patients with primary aldosteronism compared with a control population. MDM2 is therefore considered one of the mineralocorticoid-responsive genes that regulates cell proliferation of VSMCs induced by MR-mediated aldosterone stimulation, possibly playing an important role in aldosterone-induced vascular structural remodeling.
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