Evidence map›Paper›PMID 16877062›Full record

ReviewAdvances in virus research2006

The molecular biology of coronaviruses.

Paul S Masters

Registry-linked trialAbstract readReview
In one paragraph

Review in Advances in virus research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04470583 (Evaluation of Clinical Parameters Following COVID-19 Infection in Pregnancy), which is not on this map. Cited by 938 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
938citing papers in PubMed, 1 pooled it
157.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04470583 unknown statusnot on this mapstarted 2020, after this paper: background citation

Evaluation of Clinical Parameters Following COVID-19 Infection in Pregnancy (COpregVID)

TypeobservationalSponsorChelsea and Westminster NHS Foundation TrustRan2020 to 2021Enrolled116ConditionsCOVID-19, 2019 Novel Coronavirus Infection, COVID-19 Infection
3 · Its place in the literature

Who cites it

938 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,828 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
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  15. Article
  16. SARS-CoV-2 S assembly into virions facilitated by host ERM proteins.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  17. Article
  18. Suidae Coronaviruses: Epidemiology, Transmission, and Molecular Diagnosis.Animals : an open access journal from MDPI · 2026
    Review
  19. Article
  20. Review

878 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Paul S MastersWadsworth Center, New York State Department of Health, Albany, 12201, USA.
New York State Department of Health · US

Funding

Genetic Analysis of Molecular Interactions in Coronavirus ReplicationR01AI064603 · NIAID · WADSWORTH CENTER · PI MASTERS, PAUL SCOTT · 2005 to 2015
$4.7M
CORONAVIRUS RNA SYNTHESISR01AI045695 · NIAID · WADSWORTH CENTER · PI MASTERS, PAUL SCOTT · 2000 to 2004
$1.3M
SARS Coronavirus Reverse Genetics and PathogenesisR21AI060755 · NIAID · WADSWORTH CENTER · PI MASTERS, PAUL SCOTT · 2004 to 2005
$537k
Genetic Analysis of Molecular Interactions in Coronavirus ReplicationR56AI064603 · NIAID · WADSWORTH CENTER · PI MASTERS, PAUL SCOTT · 2010 to 2010
$536k
NIAID NIH HHS AI 45695NIAID NIH HHS AI 60755NIAID NIH HHS AI 64603NIAID NIH HHS R01 AI045695NIAID NIH HHS R01 AI064603NIAID NIH HHS R21 AI060755NIAID NIH HHS R56 AI064603
6 · The paper itself

Abstract

Coronaviruses are large, enveloped RNA viruses of both medical and veterinary importance. Interest in this viral family has intensified in the past few years as a result of the identification of a newly emerged coronavirus as the causative agent of severe acute respiratory syndrome (SARS). At the molecular level, coronaviruses employ a variety of unusual strategies to accomplish a complex program of gene expression. Coronavirus replication entails ribosome frameshifting during genome translation, the synthesis of both genomic and multiple subgenomic RNA species, and the assembly of progeny virions by a pathway that is unique among enveloped RNA viruses. Progress in the investigation of these processes has been enhanced by the development of reverse genetic systems, an advance that was heretofore obstructed by the enormous size of the coronavirus genome. This review summarizes both classical and contemporary discoveries in the study of the molecular biology of these infectious agents, with particular emphasis on the nature and recognition of viral receptors, viral RNA synthesis, and the molecular interactions governing virion assembly.

Indexed as

Molecular BiologyAnimalsCatsCattleCoronavirusCoronavirus InfectionsDogsHumansRatsRNA, ViralViral ProteinsVirionVirus ReplicationRNA, ViralViral Proteins

Identifiers

PMID16877062
PMCPMC7112330
OpenAlexW1544561280

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.