ArticleThe Journal of the Acoustical Society of America2006
High intensity focused ultrasound-induced gene activation in solid tumors.
Article in The Journal of the Acoustical Society of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Significant Advancements and Evolutions in Chimeric Antigen Receptor Design.International journal of molecular sciences · 2024Review
- Engineering CAR T cells for enhanced efficacy and safety.APL bioengineering · 2022Review
- Miniaturized Intracavitary Forward-Looking Ultrasound Transducer for Tissue Ablation.IEEE transactions on bio-medical engineering · 2020Article
- Effective control of tumor growth through spatial and temporal control of theranostic sodium iodide symporter (Theranostics · 2020Article
- Mechanochemical Disruption Suppresses Metastatic Phenotype and Pushes Prostate Cancer Cells toward Apoptosis.Molecular cancer research : MCR · 2019Article
- Clinical Application of High-intensity Focused Ultrasound in Cancer Therapy.Journal of Cancer · 2016Review
- Electrophysiological changes correlated with temperature increases induced by high-intensity focused ultrasound ablation.Ultrasound in medicine & biology · 2015Article
- MR-guided focused ultrasound surgery, present and future.Medical physics · 2013Review
- Induced transgene expression for the treatment of solid tumors by hematopoietic stem cell-based gene therapy.Cancer gene therapy · 2012Article
- Advancement and prospects of tumor gene therapy.Chinese journal of cancer · 2011Review
- Activation of transgene expression in skeletal muscle by focused ultrasound.Biochemical and biophysical research communications · 2009Article
- Image-guided, noninvasive, spatiotemporal control of gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Short-duration-focused ultrasound stimulation of Hsp70 expression in vivo.Physics in medicine and biology · 2008Article
- Ultrasound mediated delivery of drugs and genes to solid tumors.Advanced drug delivery reviews · 2008Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In this work, the activation of heat-sensitive trans-gene by high-intensity focused ultrasound (HIFU) in a tumor model was investigated. 4T1 cancer cells (2 x 10(6)) were inoculated subcutaneously in the hind limbs of Balb/C mice. The tumors were subsequently transducted on day 10 by intratumoral injection of a heat-sensitive adenovirus vector (Adeno-hsp70B-Luc at 2 x 10(8) pfu/tumor). On day 11, the tumors were heated to a peak temperature of 55, 65, 75, or 85 degrees C within 10-30 s at multiple sites around the center of the tumor by a 1.1- or 3.3-MHz HIFU transducer. Inducible luciferase gene expression was increased from 15-fold to 120-fold of the control group following 1.1-MHz HIFU exposure. Maximum gene activation (120-fold) was produced at a peak temperature of 65-75 degrees C one day following HIFU exposure and decayed to baseline within 7 days. HIFU-induced gene activation (75 degrees C-10 s) could be further improved by using a 3.3-MHz transducer and a dense scan strategy to 170-fold. Thermal stress, rather than nonthermal mechanical stress, was identified as the primary physical mechanism for HIFU-induced gene activation in vivo. Overall, these observations open up the possibility for combining HIFU thermal ablation with heat-regulated gene therapy for cancer treatment.
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