ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2006
Vitamin D and intact PTH status in patients with hip fracture.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Relationship between serum vitamin D and hip fracture in the elderly: a systematic review and meta-analysis.Journal of bone and mineral metabolism · 2022Pooled it
- Pooled it
- Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies.BMC public health · 2010Pooled it
- Cystatin C and risk of hip fractures in older women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Trial
- Alfacalcidol-supplemented raloxifene therapy has greater bone-sparing effect than raloxifene-alone therapy in postmenopausal Japanese women with osteoporosis or osteopenia.Journal of bone and mineral metabolism · 2012Trial
- Comparison of vitamin D, parathyroid hormone (PTH), and bone metabolism markers in hip fracture patients by fracture type and control group.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Levels of parathyroid hormone and IGF binding protein 1 and associations with mortality and hip fractures in older women.Scientific reports · 2024Article
- Levels of free thyroxine are higher in displaced pediatric supracondylar humerus fractures compared with non‑displaced fractures.Experimental and therapeutic medicine · 2024Article
- Histomorphometric analysis of patients with femoral neck fracture and 25-hydroxyvitamin D deficiency: a cross-sectional study.Journal of bone and mineral metabolism · 2024Article
- Osteomalacia Prevalence, Biochemical Profile, and Histology in Patients with Low-Energy Hip Fractures Over the Age of 45.Calcified tissue international · 2023Article
- Increased incidence among the very elderly in the 2020 Niigata Prefecture Osteoporotic Hip Fracture Study.Journal of bone and mineral metabolism · 2023Article
- The Phenotype of Bone Turnover in Patients with Fragility Hip Fracture: Experience in a Fracture Liaison Service Population.International journal of environmental research and public health · 2022Article
- Decrease in serum calcitriol (but not free 25-hydroxyvitamin D) concentration in hip fracture healing.Journal of endocrinological investigation · 2021Article
- Evaluation of Serum 25-Hydroxyvitamin DOrthopaedic surgery · 2021Article
- Vertebral fracture is associated with myocardial infarction in incident hemodialysis patients: a Korean nationwide population-based study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Correlation of serum PTH level and fracture healing speed in elderly patients with hip fracture.Journal of orthopaedic surgery and research · 2019Article
- The role of parathyroid hormone (PTH) and vitamin D in falls and hip fracture type.Aging clinical and experimental research · 2019Article
- Changes in bone metabolic profile associated with pregnancy or lactation.Scientific reports · 2019Article
- Preventive Effects of Low Parathyroid Hormone Levels on Hip Fracture in Patients with Vitamin D Deficiency.Journal of bone metabolism · 2019Article
- Low serum 25-hydroxyvitamin D increases cognitive impairment in elderly people.Journal of bone and mineral metabolism · 2019Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe prevalence of hypovitaminosis D in patients with acute hip fracture was examined in a population on Sado Island in Japan. There were 85 cases of hip fracture among this population in 2004, giving an overall incidence of hip fracture of 121.4 per 100,000 population per year. This study included 50 of the 85 cases, and these cases were defined as the hip fracture group. Patients older than 70 years without established osteoporosis who were admitted to the hospital on the island during almost the same period for treatment of an orthopedic condition other than a hip fracture were defined as the control group. MATERIALS AND
methodsThe levels of serum 25-hydroxyvitamin D (25-OHD), intact parathyroid hormone (intact PTH), alkaline phosphatase (ALP), albumin, and the number of remaining teeth were examined in each group. In the hip fracture group, serum calcium, serum phosphorus, urine N-terminal cross-linking telopeptide of type I collagen (NTx), bone mineral density (BMD) of the nonfractured hip, the presence of a vertebral fracture on X-ray, severity of dementia, and physical activity level were also examined.
resultsBoth the serum 25-OHD and serum albumin levels were significantly lower in patients with hip fracture than in controls, and the intact PTH level was significantly higher in patients with hip fracture. The number of remaining teeth was correlated with age, and was also significantly correlated with 25-OHD. In the hip fracture group, 62% of the subjects had hypovitaminosis D (25-OHD <20 ng/ml) and one-fifth of cases with hypovitaminosis D showed elevated PTH levels (>65 pg/ml). On the other hand, in the control group, hypovitaminosis D occurred in 18.9% of the subjects, and only one case showed elevated PTH. The serum 25-OHD level showed a decrease as the severity of dementia progressed and the activity level decreased.
conclusionOur results indicate that about two-thirds (62%) of hip fracture patients had vitamin D insufficiency, suggesting that this condition may be closely associated with hip fracture in elderly people. Therefore, the serum 25-OHD level may be a useful index for the risk of hip fracture in elderly people.
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