ArticleBlood2006
Enhanced VWF biosynthesis and elevated plasma VWF due to a natural variant in the murine Vwf gene.
Article in Blood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Hyperadhesive von Willebrand Factor Contributes to Pathogenesis of Preeclampsia.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
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- A Bayesian Mutation-Selection Framework for Detecting Site-Specific Adaptive Evolution in Protein-Coding Genes.Molecular biology and evolution · 2021Article
- The commonBlood advances · 2018Article
- von Willebrand factor propeptide to antigen ratio identifies platelet activation and reduced von Willebrand factor survival phenotype in mice.Journal of thrombosis and haemostasis : JTH · 2018Article
- Functional Consequences of Mannose and Asialoglycoprotein Receptor Ablation.The Journal of biological chemistry · 2016Article
- Modeling Disorders of Blood Coagulation in the Zebrafish.Current pathobiology reports · 2015Article
- Article
- Third Åland islands conference on von Willebrand disease, 26-28 September 2012: meeting report.Haemophilia : the official journal of the World Federation of Hemophilia · 2013Article
- Loss of fibrinogen in zebrafish results in symptoms consistent with human hypofibrinogenemia.PloS one · 2013Article
- Modifiers of von Willebrand factor identified by natural variation in inbred strains of mice.Blood · 2009Article
- Selection on cis-regulatory variation at B4galnt2 and its influence on von Willebrand factor in house mice.Molecular biology and evolution · 2009Article
- Article
- Genetic regulation of plasma von Willebrand factor levels: quantitative trait loci analysis in a mouse model.Journal of thrombosis and haemostasis : JTH · 2007Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Both genetic and environmental influences contribute to the wide variation in plasma von Willebrand factor (VWF) levels observed in humans. Inbred mouse strains also have highly variable plasma VWF levels, providing a convenient model in which to study genetic modifiers of VWF. Previously, we identified a major modifier of VWF levels in the mouse (Mvwf1) as a regulatory mutation in murine Galgt2. We now report the identification of an additional murine VWF modifier (Mvwf2). Mvwf2 accounts for approximately 16% of the 8-fold plasma VWF variation (or approximately 25% of the genetic variation) observed between the A/J and CASA/RkJ strains and maps to the murine Vwf gene itself. Twenty SNPs were identified within the coding regions of the A/J and CASA/RkJ Vwf alleles, and in vitro analysis of recombinant VWF demonstrated that a single SNP (+7970G>A) and the associated nonsynonymous amino acid change (R2657Q) confers a significant increase in VWF biosynthesis from the CASA/RkJ Vwf allele. This change appears to represent a unique gain of function that likely explains the mechanism of Mvwf2 in vivo. The identification of a natural Vwf gene variant among inbred mice affecting biosynthesis suggests that similar genetic variation may contribute to the wide range of VWF levels observed in humans.
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Registered trials
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