ArticleOccupational and environmental medicine2006
Maternal and paternal occupational exposure to agricultural work and the risk of anencephaly.
Article in Occupational and environmental medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- The influence of environmental exposures during the preconception period on offspring outcomes: a systematic review.Frontiers in public health · 2025Pooled it
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Preconception care: caffeine, smoking, alcohol, drugs and other environmental chemical/radiation exposure.Reproductive health · 2014Pooled it
- Incidental Prenatal Discovery of Anencephaly via Portable Ultrasounds in a Remote Medical Care Setting.Cureus · 2025Article
- Review
- Pesticide Exposures during Pregnancy and Health Outcomes in Latin America and the Caribbean: A Scoping Review of Human Observational Studies.Journal of health & pollution · 2024Review
- Exposure to Environmental Pesticides and the Risk of Autism Spectrum Disorders: A Population-Based Case-Control Study.Medicina (Kaunas, Lithuania) · 2024Article
- Global strategies for the prevention of neural tube defects through the improvement of folate status in women of reproductive age.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Impact of High-Throughput Model Parameterization and Data Uncertainty on Thyroid-Based Toxicological Estimates for Pesticide Chemicals.Environmental science & technology · 2022Article
- Environment, Lifestyle, and Female Infertility.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Gene Environment Interactions in the Etiology of Neural Tube Defects.Frontiers in genetics · 2021Review
- Repeated exposure of pyriproxyfen to pregnant female mice causes developmental abnormalities in prenatal pups.Environmental science and pollution research international · 2020Article
- Association of pesticide exposure with human congenital abnormalities.Toxicology and applied pharmacology · 2018Review
- Paternal Risk Factors for Oral Clefts in Northern Africans, Southeast Asians, and Central Americans.International journal of environmental research and public health · 2017Article
- Huichol Migrant Laborers and Pesticides: Structural Violence and Cultural Confounders.Medical anthropology quarterly · 2016Article
- Parenteral exposure to pesticides and occurence of congenital malformations: hospital-based case-control study.BMC pediatrics · 2016Article
- Observed and self-reported pesticide protective behaviors of Latino migrant and seasonal farmworkers.Environmental research · 2016Article
- Parental occupational exposures to endocrine disruptors and the risk of simple isolated congenital heart defects.Pediatric cardiology · 2015Article
- Seasonality in birth defects, agricultural production and urban location.Economics and human biology · 2014Article
- Maternal periconceptional occupational pesticide exposure and neural tube defects.Birth defects research. Part A, Clinical and molecular teratology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo evaluate the association between parental occupational exposure to agricultural work and the risk of anencephaly in three Mexican states.
methodsA paired case control study (1:1) was done based on records of the Epidemiological Surveillance System of Neural Tube Defects in Mexico; 151 cases of anencephaly of more than 20 weeks' gestation were selected between March 2000 and February 2001. Controls were selected from the same maternity services as those of the cases and were born alive without congenital malformations. Information was obtained from both parents by means of a general questionnaire, a food frequency questionnaire, and a specific questionnaire on occupational exposure to pesticides. Exposures were analysed with emphasis on the three months before and one month after the last menstruation periods (acute risk period (ARP)), as well as exposure prior to the above mentioned period (non-acute risk period (NARP)).
resultsThe children of mothers who worked in agriculture in the ARP had a greater risk of anencephaly (OR = 4.57, 95% CI 1.05 to 19.96). The risk of fathers having a child with anencephaly was greater in those who applied pesticides irrespective of whether it was done in the ARP or the NARP (OR = 2.50, 95% CI 0.73 to 8.64; and OR = 2.03, 95% CI 0.58 to 7.08, respectively).
conclusionsThese results support the hypothesis of the effect of maternal exposure to agricultural work on anencephaly and suggest that exposure of the father to pesticides in the periconceptional period or prior to this can also increase the risk of having an anencephalic child.
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Registered trials
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